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首页> 外文期刊>Journal of Agricultural and Food Chemistry >Lipid Distribution Pattern and Transcriptomic Insights Revealed the Potential Mechanism of Docosahexaenoic Acid Traffics in Schizochytrium sp. A-2
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Lipid Distribution Pattern and Transcriptomic Insights Revealed the Potential Mechanism of Docosahexaenoic Acid Traffics in Schizochytrium sp. A-2

机译：脂质分布模式和转录组洞察揭示了二十二碳六烯酸在Schizochytrium sp中的潜在机制。 A2

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摘要

Schizochytrium sp. A-2 is a heterotrophic marine fungus used for the commercial production of docosahexaenoic acid (DHA). However, the pattern of the distribution of DHA and how DHA is channeled into phospholipid (PL) and triacylglycerol (TAG) are unknown. In this study, we systematically analyzed the distribution of DHA in TAG and PL during the growth of the cell. The migration of DHA from PL to TAG was presumed during the fermentation cycle. DHA and docosapentaenoic acid were accumulated in both TAG and phosphatidylcholine (PC), whereas eicosapentaenoic acid was mainly deposited in PC. RNA seq revealed that malic enzyme may provide lipogenic NADPH. In addition, long-chain acyl-CoA synthase and acyl-CoA:lysophosphatidylcholine acyltransferase may participate in the accumulation of DHA in PL. No phosphatidylcholine:diacylglycerol cholinephosphotransferase was identified from the genome sequence. In contrast, phospholipid:diacylglycerol acyltransferase-mediated acyl-CoA-independent TAG synthesis pathway and phospholipase C may contribute to the channeling of DHA from PC to TAG.
机译：Schizochytrium sp。 A-2是用于商业生产二十二二十二碳酸（DHA）的异养的海洋真菌。然而，DHA分布的模式以及DHA如何被引入磷脂（PL）和三酰基甘油（标签）是未知的。在该研究中，我们在细胞生长过程中系统地分析了TAG和PL中DHA的分布。在发酵循环期间假定DHA从PL到标签的迁移。 DHA和Docosapentaeno酸在两种标签和磷脂酰胆碱（PC）中积聚，而偏辛烯酸主要沉积在PC中。 RNA SEQ显示苹果酵母可以提供脂肪原性NADPH。此外，长链酰基-CoA合酶和酰基 - COA：溶血磷脂酰胆碱酰基转移酶可以参与DHA在PL中的积累。没有磷脂酰胆碱：从基因组序列中鉴定二酰基甘油胆碱Phollyfofersease。相反，磷脂：二酰基甘油酰基转移酶介导的酰基-CoA独立标签合成途径和磷脂酶C可以有助于DHA从PC到标签的通道。

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