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首页> 外文期刊>Journal of Agricultural and Food Chemistry >Arsenic in Rice Bran Products: In Vitro Oral Bioaccessibility, Arsenic Transformation by Human Gut Microbiota, and Human Health Risk Assessment
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Arsenic in Rice Bran Products: In Vitro Oral Bioaccessibility, Arsenic Transformation by Human Gut Microbiota, and Human Health Risk Assessment

机译：稻麸的砷产品：体外口服生物可接受，人体肠道微生物的砷转化，人体健康风险评估

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Despite rice consumption, rice bran as a byproduct of rice milling contains higher arsenic (As). The present study evaluated the metabolic potency of in vitro cultured human colon microbiota toward As from five rice bran products with 0.471-1.491 mg of As/kg. Arsenic bioaccessibility ranged from 52.8 to 78.8% in the gastric phase, and a 1.2-fold increase (66.0-95.8%) was observed upon the small intestinal phase. Subsequently, a significant decline of As bioaccessibility (11.3-63.6%) and a high methylation percentage of 18.5-79.8% were found in the colon phase. The predominant As species in the solid phase was always As(V) (49.6-63.4%), and As thiolate complexes increased by 10% at the end of colon incubation. Human gut microbiota could induce As bioaccessibility lowering and As transformation in rice bran, which illustrated the importance of food-bound As metabolism in the human body. This will result in a better understanding of health implications associated with As exposures.
机译：尽管稻米消耗，米糠作为水稻碾磨的副产品含有更高的砷（AS）。 本研究评估了体外培养人结肠微生物的代谢效力，从50米麸皮产品中朝向0.471-1.491mg作为/ kg。 在胃相的砷生物可接受范围为52.8至78.8％，在小肠阶段观察到1.2倍的增加（66.0-95.8％）。 随后，在结肠相中发现了作为生物可接受性（11.3-63.6％）和高甲基化百分比的显着下降18.5-79.8％。 优势作为固相的物种始终为（V）（49.6-63.4％），并且在结肠孵育结束时，硫醇酸酯复合物增加了10％。 人体肠道微生物群可以诱导降低生物可接受性和随着水稻麸皮的转化，这表明了食物结合在人体中代谢的重要性。 这将导致更好地理解与暴露有关的健康影响。

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