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首页> 外文期刊>Journal of Agricultural and Food Chemistry >Synthesis, Antiviral Activity, and Induction of Plant Resistance of Indole Analogues Bearing Dithioacetal Moiety
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Synthesis, Antiviral Activity, and Induction of Plant Resistance of Indole Analogues Bearing Dithioacetal Moiety

机译：吲哚类似物轴承二缩醛部分的合成，抗病毒活性和植物抗性的诱导

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摘要

A series of compounds with potential activity to induce plant resistance was synthesized from indole and thiol compounds and methodically evaluated for antiviral activity. The results indicated that some of the synthesized compounds had high antipotato virus Y (PVY), anticucumber mosaic virus, and antitobacco mosaic virus activities. Notably, compound D21 exhibited the best activity against PVY among these compounds in vivo, and the 50% effective concentrations (EC50) of protection activity is 122 mu g/mL, which was distinctively better than the corresponding values for ribavirin (653 mu g/mL), Ningnanmycin (464 mu g/mL), and Xiangcaoliusuobingmi (279 mu g/mL). Interestingly, we found that the protection activity of D21 was associated with improvement of chlorophyll content and defense-related enzyme activities. Moreover, D21 could trigger the malate dehydrogenase (MDH) signaling pathway, as further confirmed by the MDH activity evaluation. Hence, D21 can protect plants against viral activity and has potential as a novel activator for plant resistance induction.
机译：通过吲哚和硫醇化合物合成了一系列具有诱导植物抗性的潜在活性的化合物，并有条理地评估抗病毒活性。结果表明，一些合成的化合物具有高抗痘病毒Y（PVY），抗肌肤镶嵌病毒和抗杀伤酵母叶片病毒活性。值得注意的是，化合物D21在体内的这些化合物中表现出对PVY的最佳活性，并且保护活性的50％有效浓度（EC50）为122μg/ ml，其比利巴韦林的相应值鲜明（653μg/ ml），宁南霉素（464μg/ ml）和Xiangcaoliusuobingmi（279μg/ ml）。有趣的是，我们发现D21的保护活性与改善叶绿素含量和与国防相关的酶活性有关。此外，D21可以触发亚氨基脱氢酶（MDH）信号通路，如MDH活性评估进一步证实。因此，D21可以保护植物免受病毒活性，并具有作为植物抗性诱导的新型激活剂的潜力。

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  • 作者

    Wei Chunle; Zhang Jian; Shi Jing; Gan Xiuhai; Hu Deyu; Song Baoan;

  • 作者单位

    Guizhou Univ State Key Lab Breeding Base Green Pesticide &

    Agr Key Lab Green Pesticide &

    Agr Bioengn Minist Educ Guiyang 550025 Guizhou Peoples R China;

    Guizhou Univ State Key Lab Breeding Base Green Pesticide &

    Agr Key Lab Green Pesticide &

    Agr Bioengn Minist Educ Guiyang 550025 Guizhou Peoples R China;

    Guizhou Univ State Key Lab Breeding Base Green Pesticide &

    Agr Key Lab Green Pesticide &

    Agr Bioengn Minist Educ Guiyang 550025 Guizhou Peoples R China;

    Guizhou Univ State Key Lab Breeding Base Green Pesticide &

    Agr Key Lab Green Pesticide &

    Agr Bioengn Minist Educ Guiyang 550025 Guizhou Peoples R China;

    Guizhou Univ State Key Lab Breeding Base Green Pesticide &

    Agr Key Lab Green Pesticide &

    Agr Bioengn Minist Educ Guiyang 550025 Guizhou Peoples R China;

    Guizhou Univ State Key Lab Breeding Base Green Pesticide &

    Agr Key Lab Green Pesticide &

    Agr Bioengn Minist Educ Guiyang 550025 Guizhou Peoples R China;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 营养卫生、食品卫生;农业科学;
  • 关键词

    indole; dithioacetal; antiviral activity; plant resistance induction; malate dehydrogenase;

    机译：吲哚;二缩醛;抗病毒活性;植物抗性诱导;苹果酸脱氢酶;

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