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首页> 外文期刊>Journal of Agricultural and Food Chemistry >Correlation Analysis of Intestinal Redox State with the Gut Microbiota Reveals the Positive Intervention of Tea Polyphenols on Hyperlipidemia in High Fat Diet Fed Mice
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Correlation Analysis of Intestinal Redox State with the Gut Microbiota Reveals the Positive Intervention of Tea Polyphenols on Hyperlipidemia in High Fat Diet Fed Mice

机译：肠道微生物肠肠红外极洲的相关分析揭示了茶多酚对高脂饮食喂养小鼠的高脂血症的正干预

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Tea polyphenols (TP) possess the ability to regulate dyslipidemia and gut microbiota dysbiosis. However, the underlying mechanism is still elusive. The present study explored the intervention of TP on high fat diet induced metabolic disorders, gut microbiota dysbiosis in mice, and the underlying intestinal mechanism. As a result, TP significantly ameliorated hyperlipidemia, improved the expression levels of hepatic lipid metabolism genes, and modulated gut microbiota. The underlying mechanism was supposed to rely on the maintaining of intestinal redox state by TP. Intestinal redox related indicators were significantly correlated with the distribution of gut microbiota. An unidentified genus of Lachnospiraceae, Bacteroides, Alistipes, and Faecalibaculum were identified as the biomarkers for intestinal redox state. Importantly, different dosages of TP modulated intestinal redox state and gut microbiota in varied patterns, and an overdose intake attenuated the beneficial effects on gut health. Our findings offered novel insights into the mechanism of TP on intestinal homeostasis.
机译：茶多酚（TP）具有调节血脂血症和肠道微生物症脱敏病的能力。然而，潜在的机制仍然难以捉摸。本研究探讨了TP对高脂肪饮食诱导的代谢障碍，小鼠肠道微生物症的诱导症，以及肠道机制。结果，TP显着改善高脂血症，改善了肝脂代谢基因的表达水平，以及调制的肠道微生物。潜在的机制应该依赖于TP维持肠道氧化还原态。肠氧化还原相关的指标与肠道微生物的分布显着相关。鉴定了Lachnospiraceae，诱导菌，杀菌剂和粪便菌和粪便的身份不明的属植物作为肠氧化还原状态的生物标志物。重要的是，不同模式的不同剂量的TP调节肠道氧化还原状态和肠道微生物肿块，并且过量摄入量减弱了对肠道健康的有益效果。我们的研究结果为TP对肠道稳态的机制提供了新的洞察力。

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