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首页> 外文期刊>Journal of Applied Polymer Science >Bioinspired polydopamine coating-assisted electrospun polyurethane-graphene oxide nanofibers for bone tissue engineering application
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Bioinspired polydopamine coating-assisted electrospun polyurethane-graphene oxide nanofibers for bone tissue engineering application

机译：Bioinspired聚二胺涂层辅助电纺 - 石墨烯氧化物纳米纤维用于骨组织工程应用

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摘要

It is inevitable to replace the tissues and organs that have been malfunctioning due to trauma or difference diseases, so tissue engineering can be a promising approach in case of regeneration. In this investigation, electrospun polyurethane-graphene oxide scaffold was coated with polydopamine (PDA) by immersing the constructs in dopamine hydrochloride solution under the alkaline condition for 24 h. The present study aimed to investigate the synergic effects of graphene oxide (GO) and PDA on the osteogenic expression. Field emission scanning electron microscopy, Fourier transform infrared spectrum, and X-ray diffraction (XRD) proved the synthesis of GO. Water drop contact angle and swelling absorption test indicated significantly enhancement in hydrophilicity after coating the scaffolds with PDA. Besides, PDA induced more ability of mineralization bone-like component. According to the results, cell attachment and proliferation were greatly increased in coated constructs. Alkaline phosphatase expression was also increased on the PDA-deposited polymeric scaffolds. In general, these characteristics suggest that the PDA-coated polyurethane-GO scaffolds are an appropriate substrate for in vivo studies and the bone regeneration. (c) 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2019, 136, 47656.
机译：替代由于创伤或差异疾病导致的组织和器官替代组织和器官，因此在再生的情况下，组织工程可以是有希望的方法。在该研究中，通过将多胺（PDA）浸入碱性条件下浸入24小时的多巴胺盐酸盐溶液中的构建体涂覆电纺 - 聚氨酯 - 石墨烯氧化物支架。本研究旨在探讨石墨烯（GO）和PDA对成骨表达的协同作用。场发射扫描电子显微镜，傅里叶变换红外光谱和X射线衍射（XRD）证明了Go的合成。水滴接触角和溶胀吸收试验表明用PDA涂覆支架后的亲水性显着增强。此外，PDA诱导矿化骨状成分的更多能力。根据结果​​，在涂覆的构建体中大大增加了细胞附着和增殖。在PDA沉积的聚合物支架上也增加了碱性磷酸酶表达。通常，这些特性表明PDA涂覆的聚氨酯 - 去支架是体内研究和骨再生的适当底物。 （c）2019 Wiley期刊，Inc.J.Phill。聚合物。 SCI。 2019,136,47656。

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