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Synergized poly(lactic acid)-hydroxyapatite composites: Biocompatibility study

机译:协同聚(乳酸) - 羟基磷灰石复合材料:生物相容性研究

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摘要

In vitro biocompatibility of impact modified composites produced from poly(lactic acid) (PLA) and hydroxyapatite (HA) is reported in this study. Surface modification was previously used to facilitate the dispersion of HA in PLA, whereas impact property of the PLA-HA composites was deliberately enhanced as it was necessary. Herein, osteoblast cell culture assay was used to assess the possible effects of HA surface modification and impact modification on the cell behavior in physiological media. Furthermore, antimicrobial properties of the HA were assessed. Evidence of HA modification was confirmed through elemental and spectroscopic analysis. Incorporation of HA offered better cell attachment and proliferation to the PLA matrix, with significant increase in the cell viability (%). Also, modification of HA did not present obvious cytotoxicity to the PLA-HA composite. Conversely, incorporation of impact modifier slowed down the rate of cell proliferation on the composite surface but facilitates increased wettability. (C) 2018 Wiley Periodicals, Inc.
机译:在由聚(乳酸)产生的冲击改性材料的体外生物相容性(PLA)和羟基磷灰石(HA)中报道了此研究。表面改性以前使用,以便HA的PLA分散体中,而PLA-HA复合材料的冲击性能是故意增强,因为它是必要的。在本文中,成骨细胞的细胞培养测定法来评估HA表面改性和抗冲改性在生理介质中的细胞行为的可能的影响。此外,HA的抗微生物性质进行了评估。 HA修改的证据是通过元素和光谱分析确认。 HA的加入提供了更好的细胞附着和增殖解放军矩阵,在细胞活力(%)显著上升。此外,医管局的修改并没有表现出明显的细胞毒作用的PLA-HA复合材料。相反,冲击改性剂的掺入减慢细胞增殖的速率的复合材料表面上,但功能有助于提高润湿性。 (c)2018 Wiley期刊,Inc。

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