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首页> 外文期刊>Journal of Applied Polymer Science >Theophylline-loaded pectin-based hydrogels. II. Effect of concentration of initial pectin solution, crosslinker type and cation concentration of external solution on drug release profile
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Theophylline-loaded pectin-based hydrogels. II. Effect of concentration of initial pectin solution, crosslinker type and cation concentration of external solution on drug release profile

机译：培养基加载果胶基水凝胶。 II。 初始果胶溶液浓度，交联剂型和外溶液浓度对药物释放曲线的影响

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摘要

A series of drug-loaded pectin hydrogels were prepared by mixing method in two ion types, Ca+2 or Zn+2, for wound dressing applications and their drug release performances were investigated at pH 6.4 in four different calcium ion concentrations of external solution. Pectin hydrogels were synthesized in three different concentrations of initial pectin solution and theophylline was used as a model drug. Fourier transform infrared spectroscopy, scanning electron microscopy, and atomic force microscopy were used for hydrogel characterization. Additionally, fluid handling capacity, swelling behavior, dehydration rate, dispersion characteristic, dressing pH determination, water vapor permeability, oxygen permeability, surface contact angle, flexibility, mass per unit area, and thickness were determined for selected hydrogels. One of the most valuable contributions of our study is that the concentration of initial pectin solution and calcium ion concentration of external solution are very important parameters to obtain an effective drug release. After evaluating all data, we have shown that flexible and transparent pectin-based wound dressings can be synthesized as a controlled drug release system. Zinc-containing hydrogel was antibacterial against Staphylococcus aureus and Escherichia coli but not suitable for cell migration. On the other hand, calcium-based hydrogel was nontoxic on the fibroblast cells and it had no negative effect on cell migration. (c) 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2019, 136, 48155.
机译：通过在两种离子类型，Ca + 2或Zn + 2中混合方法制备一系列药物果胶水凝胶，用于伤口敷料应用，并在四种不同的外溶液中的pH 6.4中研究其药物释放性能。在三种不同浓度的初始果胶溶液中合成果胶水凝胶，茶碱用作模型药物。傅里叶变换红外光谱，扫描电子显微镜和原子力显微镜用于水凝胶表征。另外，对于选定的水凝胶，确定流体处理能力，膨胀行为，脱水速率，分散特性，敷料pH测定，水蒸气渗透性，氧气渗透性，表面接触角，柔韧性，质量。我们研究中最有价值的贡献之一是初始果胶溶液的浓度和外部溶液的钙离子浓度是获得有效药物释放的非常重要的参数。在评估所有数据之后，我们已经表明，柔性透明果胶的卷绕敷料可作为受控药物释放系统合成。含锌的水凝胶是对金黄色葡萄球菌和大肠杆菌的抗菌，但不适合细胞迁移。另一方面，钙的水凝胶在成纤维细胞上无毒，对细胞迁移没有负面影响。 （c）2019 Wiley期刊，Inc.J.Phill。聚合物。 SCI。 2019,136,48155。

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