...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of Cell Science >Regulation of dendrite morphology and excitatory synapse formation by zDHHC15
【24h】

Regulation of dendrite morphology and excitatory synapse formation by zDHHC15

机译：ZDHC15调节树突形态和兴奋性突触形成

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Protein palmitoylation is the most common post-translational lipid modification in the brain and is mediated by a family of 24 zDHHC enzymes. There has been growing interest in zDHHCs due to mounting evidence that these enzymes play key roles in the development and function of neuronal connections, and the fact that a number of zDHHCs have been associated with neurodevelopmental and neurodegenerative diseases. Loss-of-function variants in several zDHHCs, including zDHHC15, have been identified in patients with intellectual disabilities; however, the function of zDHHC15 in the brain has not been well studied. Here, we demonstrate that knocking down zDHHC15 in primary rat hippocampal cultures reduces dendritic outgrowth and arborization, as well as spine maturation. Moreover, knockdown of zDHHC15 reduces palmitoylation of PSD-95 and its trafficking into dendrites, resulting in an overall decrease in the density of excitatory synapses being formed onto mutant cells.
机译：蛋白质棕榈酰化是脑中最常见的翻译后脂质改性，并由24个ZDHHC酶的家族介导。 由于安装证据表明这些酶在神经元连接的开发和功能中发挥关键作用，因此对ZDHCS产生了兴趣，并且许多ZDHCS与神经发育和神经变性疾病相关的事实。 在智障障碍患者中鉴定了几种ZDHCS中的函数损失变体，包括ZDHHC15，智障患者; 然而，大脑中ZDHC15的功能尚未得到很好的研究。 在这里，我们证明敲击原代大鼠海马培养物中的ZDHC15减少树突过剩和植物，以及脊柱成熟。 此外，ZDHHC15的敲低将PSD-95的棕榈酰基降低，其运输到树枝状内部，导致兴奋性突触的密度整体下降到突变细胞上。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号