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Centriole assembly at a glance

机译:厘升

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The centriole organelle consists of microtubules (MTs) that exhibit a striking 9-fold radial symmetry. Centrioles play fundamental roles across eukaryotes, notably in cell signaling, motility and division. In this Cell Science at a Glance article and accompanying poster, we cover the cellular life cycle of this organelle – from assembly to disappearance – focusing on human centrioles. The journey begins at the end of mitosis when centriole pairs disengage and the newly formed centrioles mature to begin a new duplication cycle. Selection of a single site of procentriole emergence through focusing of polo-like kinase 4 (PLK4) and the resulting assembly of spindle assembly abnormal protein 6 (SAS-6) into a cartwheel element are evoked next. Subsequently, we cover the recruitment of peripheral components that include the pinhead structure, MTs and the MT-connecting A-C linker. The function of centrioles in recruiting pericentriolar material (PCM) and in forming the template of the axoneme are then introduced, followed by a mention of circumstances in which centrioles form de novo or are eliminated.
机译:沿着微管器(MTS)组成,所述微管(MTS)表现出引人注目的9倍径向对称性。半个硅酸件在真核生物上发挥基本作用,特别是在细胞信号,运动和划分中。在这款细胞科学的一篇目剧观目的文章和伴随海报中,我们覆盖了这种细胞器的蜂窝生命周期 - 从组装到消失 - 专注于人中的亚料。当沿着拐点对脱离和新形成的半聚硅酸纤维成熟开始新的复制循环时,旅程开始于有丝分裂结束时。选择通过聚焦Polo样激酶4(PLK4)和由所得主轴组件异常蛋白6(SAS-6)的所得组件进入车轮元件中的单个网状眼镜的出现。随后,我们涵盖了包括针头结构,MTS和MT连接A-C接头的外围部件的招募。然后引入了半硅烷在募集脑膜材料(PCM)和形成轴突模板中的函数,然后提到内甲基硅酸酯形式或被消除的情况。

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