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首页> 外文期刊>Journal of Cell Science >The mitochondrial phosphatidylserine decarboxylase Psd1 is involved in nitrogen starvation-induced mitophagy in yeast
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The mitochondrial phosphatidylserine decarboxylase Psd1 is involved in nitrogen starvation-induced mitophagy in yeast

机译：线粒体磷脂酰丝氨酸脱羧酶PSD1参与酵母中的氮饥饿诱导的乳化物

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摘要

Mitophagy, the selective degradation of mitochondria by autophagy, is a central process that is essential for the maintenance of cell homeostasis. It is implicated in the clearance of superfluous or damagedmitochondria and requires specific proteins and regulators to perform. In yeast, Atg32, an outer mitochondrial membrane protein, interacts with the ubiquitin-like Atg8 protein, promoting the recruitment of mitochondria to the phagophore and their sequestration within autophagosomes. Atg8 is anchored to the phagophore and autophagosome membranes thanks to a phosphatidylethanolamine tail. In Saccharomyces cerevisiae, several phosphatidylethanolamine synthesis pathways have been characterized, but their contribution to autophagyand mitophagyare unknown. Through different approaches, we show that Psd1, the mitochondrial phosphatidylserine decarboxylase, is involved in mitophagy induction only after nitrogen starvation, whereas Psd2, which is located in vacuole, Golgi and endosome membranes, is required preferentially for mitophagy induction in the stationary phase of growth but also to a lesser extent for nitrogen starvation-inducedmitophagy. Our results suggest that the mitophagy defect observed in.psd1 yeast cells after nitrogen starvation may be due to a failure of Atg8 recruitment to mitochondria.
机译：MINOCHAGY，通过自噬的线粒体选择性降解是一种中心过程，对维持细胞稳态至关重要。它涉及多余或受损的血管粒细胞的间隙，并且需要特定的蛋白质和调节剂进行。在酵母中，ATG32，外部线粒体膜蛋白，与泛素状的ATG8蛋白相互作用，促进线粒体募集到噬菌体中的植物学及其在自噬体内的封存。由于磷脂酰乙醇胺尾巴，ATG8锚定到吞噬细胞和自噬膜。在酿酒酵母中，已经表征了几种磷脂酰乙醇胺合成途径，但它们对自噬囊肿的贡献未知。通过不同的方法，我们表明PSD1，线粒体磷脂酰丝氨酸脱羧酶仅在氮饥饿后涉及MITOphagy诱导，而位于真空，高尔基和高层膜中的PSD2优先考虑生长的静止阶段的MITOCOCOOPAGY诱导而且还在较小程度上进行氮饥饿诱导的诱导型。我们的研究结果表明，在氮饥饿后观察到的细菌缺陷可能是由于ATG8募集到线粒体的失败。

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