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首页> 外文期刊>Journal of chromatography, A: Including electrophoresis and other separation methods >Analytical and preparative enantioseparations in supercritical fluid chromatography using different brands of immobilized cellulose tris (3,5-dichlorophenylcarbamate) columns: Some differences
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Analytical and preparative enantioseparations in supercritical fluid chromatography using different brands of immobilized cellulose tris (3,5-dichlorophenylcarbamate) columns: Some differences

机译：使用不同品牌的固定化纤维素三（3,5-二氯苯基氨基甲酸酯）柱的超临界流体色谱分析和制备映像分析和制备分配分析：一些差异

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摘要

The aim of this study was to determine the impact of the origin and the manufacturing processes of the chiral stationary phases (CSPs) on their chromatographic behaviors. Hence, four chiral stationary phases based on immobilized tris (3,5-dichlorophenylcarbamate) derivative of cellulose supplied by four different manufacturers were evaluated. A set of twenty-nine compounds, including commercially available and inhouse synthesized compounds, with a broad range of lipophilicity and polarity was chosen. Three main parameters were evaluated on all stationary phases: retention factor, selectivity and loading capacity. This work highlighted that the retention factor strongly varied according to the manufacturer. Regardless of the characteristic of the tested compounds i.e. neutral, acidic or basic, there was a trend in retention ability of the four chiral stationary phases: retention was increasing from CHIRAL ART Cellulose-SC, REFLECT I-Cellulose C, Chiralpak IC to Lux i-Cellulose-5. On the contrary, selectivity did not follow the same trend as retention. The difference in selectivity between each column towards one compound was quite low while the difference in resolution depended on the nature of the compounds investigated and was significant in certain cases. Finally, the four different columns presented similar and high loading capacity. (C) 2020 Elsevier B.V. All rights reserved.
机译：本研究的目的是确定原产地和手性固定阶段（CSP）的制造过程对其色谱行为的影响。因此，评估基于四种不同制造商提供的纤维素的固定的TRIS（3,5-二氯苯基氨基甲酸酯）衍生物的四个手性固定相。选择了一组二十九种化合物，包括市售和加工合成化合物，具有广泛的亲脂性和极性。在所有固定阶段评估三个主要参数：保留因子，选择性和装载能力。这项工作突出显示保留因子根据制造商强烈变化。无论测试化合物的特征如何，即中性，酸性或碱性，患有四个手性固定阶段的保留能力的趋势：保留从手性艺术纤维素-Sc增加，反射I-纤维素C，Chiralpak IC到Lux I - 细胞-5。相反，选择性没有遵循与保留相同的趋势。每柱朝向一种化合物之间的选择性差异非常低，而分辨率的差异依赖于所研究的化合物的性质，在某些情况下显着显着。最后，四个不同的柱呈现出类似和高负载能力。 （c）2020 Elsevier B.v.保留所有权利。

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