An automated sample preparation approach for routine liquid chromatography tandem-mass spectrometry measurement of the alcohol biomarkers phosphatidylethanol 16:0/18:1, 16:0/16:0 and 18:1/18:1

Casati Sara; Ravelli Alessandro; Angeli Ilaria; Durello Renato; Minoli Mauro; Orioli Marica

首页> 外文期刊>Journal of chromatography, A: Including electrophoresis and other separation methods >An automated sample preparation approach for routine liquid chromatography tandem-mass spectrometry measurement of the alcohol biomarkers phosphatidylethanol 16:0/18:1, 16:0/16:0 and 18:1/18:1

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An automated sample preparation approach for routine liquid chromatography tandem-mass spectrometry measurement of the alcohol biomarkers phosphatidylethanol 16:0/18:1, 16:0/16:0 and 18:1/18:1

机译：用于常规液相色谱的自动样品制备方法串联质谱法测定醇生物标志物磷脂酰乙醇16：0/18：1，16：0/16：0和18：1/18：1

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Background: Phosphatidylethanols (PEths) are currently under investigation as highly sensitive and specific direct biomarkers of long-term alcohol abuse. PEths belong to a group of aberrant phospholipids formed in erythrocyte membranes in presence of ethanol by the catalytic action of the enzyme phospholipase Don phosphatidylcholine. Compared to other alcohol biomarkers, a higher sensitivity (94.5-100%) and specificity (100%) characterizes PEth species.

机译：背景：磷脂基乙醇（PETHS）目前正在调查中作为长期酒精滥用的高度敏感和特异性的直接生物标志物。通过酶磷脂酶DIN磷脂酰胆碱的催化作用，Peths属于在乙醇存在下形成的异常磷脂。与其他醇生物标志物相比，较高的敏感性（94.5-100％）和特异性（100％）表征了Peth物种。

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来源
《Journal of chromatography, A: Including electrophoresis and other separation methods》 |2019年第2019期|共9页
作者
Casati Sara; Ravelli Alessandro; Angeli Ilaria; Durello Renato; Minoli Mauro; Orioli Marica;
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作者单位

Univ Milan Dept Biomed Surg &

Dent Sci Lab Forens Toxicol Milan Italy;

Univ Milan Dept Biomed Surg &

Dent Sci Lab Forens Toxicol Milan Italy;

Univ Milan Dept Biomed Surg &

Dent Sci Lab Forens Toxicol Milan Italy;

Baranzate Alcohol Operat Nucleus Milan Italy;

Univ Milan Dept Biomed Surg &

Dent Sci Lab Forens Toxicol Milan Italy;

Univ Milan Dept Biomed Surg &

Dent Sci Lab Forens Toxicol Milan Italy;

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原文格式 PDF
正文语种 eng
中图分类分析化学;
关键词
Alcohol abuse; Phosphatidylethanol; Sample preparation; Biomarker; HPLC-MS/MS; Mass spectrometry;

机译：酒精滥用;磷脂酰乙醇;样品制备;生物标志物;HPLC-MS / MS;质谱;

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1. An automated sample preparation approach for routine liquid chromatography tandem-mass spectrometry measurement of the alcohol biomarkers phosphatidylethanol 16:0/18:1, 16:0/16:0 and 18:1/18:1 [J] . Casati Sara, Ravelli Alessandro, Angeli Ilaria, Journal of chromatography, A: Including electrophoresis and other separation methods . 2019,第期

机译：用于常规液相色谱的自动样品制备方法串联质谱法测定醇生物标志物磷脂酰乙醇16：0/18：1，16：0/16：0和18：1/18：1
2. Measurement of oxygen isotope ratios (O-18/O-16) of aqueous O-2 in small samples by gas chromatography/isotope ratio mass spectrometry [J] . Pati Sarah G., Bolotin Jakov, Brennwald Matthias S., Rapid Communications in Mass Spectrometry: RCM . 2016,第6期

机译：气相色谱/同位素比质谱法测量小样品中O-2水溶液的氧同位素比（O-18 / O-16）
3. A readily O-16-/O-18-isotopically-paired chiral derivatization approach for the quantification of 2-HG metabolic panel by liquid chromatography-Tandem mass spectrometry [J] . Zheng Jia-Yi, Jiang Xue, Zhou Jian-Liang, Analytica chimica acta . 2019,第期

机译：一种易于o-16- / O-18-同位素配对的手性衍生化方法，用于通过液相色谱 - 串联质谱法定量2-Hg代谢板
4. The Influence of C16:C18 Fatty Alcohol Combinations on Microstructure, Rheology and Thermal Propertiesof Fatty Alcohol-Tween 60-Water Ternary Systems [C] . Hoang Vu Dang, Peter Scholes, Jason Dove, Controlled Release Society annual meeting . 2004

机译：C16：C18脂肪醇组合对脂肪醇-吐温60-水三元体系的结构，流变学和热学性能的影响
5. Qualitative assessments and computational techniques for the studies of microbial diversity based on terminal restriction fragment length polymorphism (T-RFLP) of 16S and 18S rRNA gene sequences [D] . Shyu, Conrad. 2006

机译：基于16S和18S rRNA基因序列的末端限制性片段长度多态性（T-RFLP）的微生物多样性研究的定性评估和计算技术
6. Differences in the Synthesis and Elimination of Phosphatidylethanol 16:0/18:1 and 16:0/18:2 after Acute Doses of Alcohol [O] . Nathalie Hill-Kapturczak, Donald M. Dougherty, John D. Roache, -1

机译：急性饮酒后磷脂酰乙醇16：0/18：1和16：0/18：2的合成和消除差异
7. Quantification of phosphatidylethanol 16:0/18:1, 18:1/18:1, and 16:0/16:0 in venous blood and venous and capillary dried blood spots from patients in alcohol withdrawal and control volunteers [O] . Kummer, Natalie, Ingels, Ann Sofie A.S., Wille, Sarah M R S.M.R., 2016

机译：酒精戒断和控制志愿者的静脉血以及静脉和毛细血管干血斑中的磷脂酰乙醇16：0/18：1、18：1/18：1和16：0/16：0的定量
8. The nu2 bands of O-16O-18O-16 and O-16O-16O-18: Line positions and intensities [R] . Flaud, J.-M., Camy-Peyret, C., Ngom, A., 1988

机译：O-16O-18O-16和O-16O-16O-18的nu2波段：线位置和强度

An automated sample preparation approach for routine liquid chromatography tandem-mass spectrometry measurement of the alcohol biomarkers phosphatidylethanol 16:0/18:1, 16:0/16:0 and 18:1/18:1

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