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首页> 外文期刊>Current opinion in psychiatry >Hepatitis C and substance use: New treatments and novel approaches
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Hepatitis C and substance use: New treatments and novel approaches

机译：丙型肝炎和药物滥用：新疗法和新方法

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Purpose of Review: To provide an update on new treatment approaches for patients with hepatitis C virus (HCV) infection and substance use. This issue is of extreme importance for HCV, as many patients have substance-use histories. Recent Findings: Recent emergence of two new protease inhibitors, boceprevir and telaprevir, to enhance the modern treatment of HCV have boosted the sustained virologic response rate to about 80%, a 30% increase over prior standard of care with interferon and ribavirin. Unfortunately, many providers are reluctant to treat patients with substance-use histories unless they have demonstrated abstinence for at least 6 months, and there is a spoken and unspoken bias against these patients. Emerging new studies have shown that even current injection drug users can be treated successfully with results comparable to patients who are abstinent and those with no drug-use histories, especially with attention to the patient's substance use and other psychiatric problems. Summary: Newer treatment approaches for HCV will help many more patients than ever before to overcome the virus. Changed attitudes and innovative approaches to patients with substance-use histories are needed to bring these scientific advances to this segment of the population of patients with HCV.
机译：审查目的：提供有关丙型肝炎病毒（HCV）感染和药物使用的新治疗方法的最新信息。这个问题对于HCV极为重要，因为许多患者都有吸毒史。最新发现：最近出现了两种新的蛋白酶抑制剂boceprevir和telaprevir，以增强HCV的现代治疗效果，将持续的病毒学应答率提高到约80％，比干扰素和利巴韦林以前的治疗标准提高了30％。不幸的是，除非提供者至少有6个月禁欲，并且有针对这些患者的口头和不言而喻的偏见，否则许多提供者都不愿对有药物使用史的患者进行治疗。新兴的新研究表明，即使是目前的注射吸毒者，也可以成功治疗，其结果可与戒酒和无吸毒史的患者相提并论，尤其是要注意患者的药物使用和其他精神疾病。简介：较新的HCV治疗方法将比以往帮助更多的患者克服该病毒。需要对药物使用史的患者改变态度并采用创新的方法，以将这些科学进展带给这部分HCV患者。

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