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首页> 外文期刊>Journal of Materials Science >Rheological behavior, 3D printability and the formation of scaffolds with cellulose nanocrystals/gelatin hydrogels
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Rheological behavior, 3D printability and the formation of scaffolds with cellulose nanocrystals/gelatin hydrogels

机译：具有纤维素纳米晶体/明胶水凝胶的流变行为，3D可印刷性和支架的形成

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摘要

Recently, the CNC/GEL (cellulose nanocrystals/gelatin) composite hydrogel has been used as a biomaterial for 3D printing of tissue engineering scaffolds. Rheological properties of hydrogel have been regarded as one of the most important factors affecting printing quality, especially the viscosity recover time. However, there is still a lack of comprehensive research on the rheology property of the CNC/GEL hydrogel in the process of 3D printing. In this study, the CNC was isolated fromHumulus japonicus, and a CNC/GEL hydrogel system was prepared. The rheological properties of CNC/GEL hydrogel were evaluated using a rotary rheometer. The viscosity recovery time of the CNC/GEL hydrogel was measured using a special method. The optimal ratio of hydrogel was obtained by rheology experiment and mechanical test. The flow field distribution of the hydrogel in the flow passage of 3D printer was analyzed using fluent simulation. The rheological parameters of a hydrogel can be adjusted by changing the printing conditions. Thus, the effect of printing conditions on the formation of CNC/GEL filaments was also investigated. Finally, the biocompatibility of the printed CNC/GEL scaffold after crosslinking treatment was verified using CCK-8 and Hoechst 33342/PI double-staining assays. The present study shows a new approach for the analysis of rheological properties of CNC/GEL and also provides some suggestions for 3D printing of CNC/GEL scaffolds.
机译：最近，CNC /凝胶（纤维素纳米晶体/明胶）复合水凝胶已被用作组织工程支架的3D印刷的生物材料。水凝胶的流变性质被认为是影响印刷质量的最重要因素之一，尤其是粘度恢复时间。然而，仍然缺乏对3D印刷过程中CNC /凝胶水凝胶的流变性质的综合研究。在该研究中，CNC从Humulus japonicus中分离出来，制备CNC /凝胶水凝胶系统。使用旋转流变仪评价CNC /凝胶水凝胶的流变性质。使用特殊方法测量CNC /凝胶水凝胶的粘度恢复时间。通过流变实验和机械测试获得水凝胶的最佳比率。通过流畅的模拟分析了3D打印机流动通道中水凝胶的流场分布。通过改变印刷条件，可以调节水凝胶的流变参数。因此，还研究了印刷条件对CNC /凝胶细丝形成的影响。最后，使用CCK-8和Hoechst 33342 / PI双染料测定验证了交联处理后印刷的CNC /凝胶支架的生物相容性。本研究表明了一种新方法，用于分析CNC /凝胶的流变性质，并对CNC /凝胶支架的3D印刷提供了一些建议。

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  • 来源
    《Journal of Materials Science》 |2020年第33期|共17页
  • 作者

    Jiang Yani; Zhou Jiping; Feng Cheng; Shi Hongcan; Zhao Guoqi; Bian Yixiang;

  • 作者单位

    Yangzhou Univ Coll Mech Engn 196 West Huayang Rd Yangzhou Jiangsu Peoples R China;

    Yangzhou Univ Coll Mech Engn 196 West Huayang Rd Yangzhou Jiangsu Peoples R China;

    Yangzhou Univ Coll Anim Sci &

    Technol 48 East Wenhui Rd Yangzhou Jiangsu Peoples R China;

    Yangzhou Univ Med Coll 11 Huaihai Rd Yangzhou Jiangsu Peoples R China;

    Yangzhou Univ Coll Anim Sci &

    Technol 48 East Wenhui Rd Yangzhou Jiangsu Peoples R China;

    Yangzhou Univ Coll Mech Engn 196 West Huayang Rd Yangzhou Jiangsu Peoples R China;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 工程材料学;
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