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Deciphering the Rules of in Silico Autophagy Methods for Expediting Medicinal Research

机译:解读用于加速药用研究的硅自噬方法规则

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摘要

Autophagy is a highly evolutionarily conserved cellular catabolic process responsible for degradation of damaged organelles and long-lived proteins. It is not surprising that scientific interest in the connection of autophagy and diseases has been growing. Over the past 2 decades, many new experimental approaches have been emerging in the field of targeting autophagy for medicinal research. Interestingly, in addition to experimental methods, a number of databases, Web servers, mathematics models, omics approaches, and systems biology network approaches related to autophagy have become available online, which may be collectively considered to be "in silico autophagy methods" for expediting current medicinal research. Thus, we have summarized a series of relevant in silico autophagy approaches for promoting the most appropriate usage of these resources for potential therapeutic purposes.
机译:自噬是一种高度进化的蜂窝分解代谢过程,负责受损的细胞器和长寿命蛋白质的降解。 对自噬和疾病联系的科学兴趣并不令人惊讶。 在过去的2世纪数十年中,在针对药用研究的靶向自噬的领域中出现了许多新的实验方法。 有趣的是,除了实验方法之外,与自噬相关的许多数据库,网络服务器,数学模型,OMIC方法和系统生物网络方法都可以在线获得,这可能被共同被认为是“在Silico自噬方法”中以便加速 目前的药用研究。 因此,我们已经总结了一系列在硅的自噬方法中相关,以促进这些资源的最合适的使用,以获得潜在的治疗目的。

著录项

  • 来源
    《Journal of Medicinal Chemistry》 |2019年第15期|共12页
  • 作者单位

    Sichuan Univ West China Hosp State Key Lab Biotherapy Chengdu 610041 Sichuan Peoples R China;

    Sichuan Univ West China Hosp State Key Lab Biotherapy Chengdu 610041 Sichuan Peoples R China;

    Sichuan Univ Coll Life Sci Key Lab Bioresources &

    Ecoenvironm Ctr Growth Metab &

    Aging Chengdu 610064 Sichuan Peoples R China;

    Nanjing Univ Sch Life Sci Dept Biotechnol &

    Pharmaceut Sci State Key Lab Pharmaceut Biotechnol Nanjing 210023 Jiangsu Peoples R China;

    Sichuan Univ West China Hosp State Key Lab Biotherapy Chengdu 610041 Sichuan Peoples R China;

    Sichuan Univ West China Hosp State Key Lab Biotherapy Chengdu 610041 Sichuan Peoples R China;

  • 收录信息
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 药学;
  • 关键词

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