Bacterial Iron Uptake Pathways: Gates for the Import of Bactericide Compounds

Schalk Isabelle J.; Mislin Gaetan L. A.

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Bacterial Iron Uptake Pathways: Gates for the Import of Bactericide Compounds

机译：细菌铁摄取途径：用于进口杀菌化合物的栅极

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Bacterial resistance to most antibiotics in clinical use has reached alarming proportions. A challenge for modern medicine will be to discover new antibiotics or strategies to combat multidrug resistant bacteria, especially Gram-negative bacteria for which the situation is particularly critical. Vectorization of bactericide compounds by siderophores (iron chelators produced by bacteria) is a promising strategy able to considerably increase the efficacy of drugs. Such a Trojan horse strategy can also extend activity of specific Gram-positive antibiotics to Gram-negative bacteria.

机译：临床用途对大多数抗生素的细菌性达到了惊人的比例。对现代医学的挑战将发现新的抗生素或战略，以打击多药抗性细菌，特别是革兰阴性细菌，其中局势特别关键。杀菌化合物的向量化通过施手（细菌产生的铁螯合剂）是能够大大增加药物疗效的有希望的策略。这种特洛伊木马策略还可以将特定革兰氏阳性抗生素的活动扩展到革兰氏阴性细菌。

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《Journal of Medicinal Chemistry》 |2017年第11期|共4页
作者
Schalk Isabelle J.; Mislin Gaetan L. A.;
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Univ Strasbourg ESBS UMR7242 Blvd Sebastien Brant F-67413 Illkirch Graffenstaden France;

Univ Strasbourg ESBS UMR7242 Blvd Sebastien Brant F-67413 Illkirch Graffenstaden France;

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正文语种 eng
中图分类药学;
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1. Bacterial Iron Uptake Pathways: Gates for the Import of Bactericide Compounds [J] . Schalk Isabelle J., Mislin Gaetan L. A. Journal of Medicinal Chemistry . 2017,第11期

机译：细菌铁摄取途径：用于进口杀菌化合物的栅极
2. Fate of ferrisiderophores after import across bacterial outer membranes: different iron release strategies are observed in the cytoplasm or periplasm depending on the siderophore pathways [J] . Isabelle J. Schalk, Laurent Guillon Amino acids . 2013,第5期

机译：跨细菌外膜导入后，铁铁载体的命运：根据铁载体途径，在细胞质或周质中观察到不同的铁释放策略
3. The synthesis and antibacterial activity of two pyoverdin-ampicillin conjugates, entering Pseudomonas aeruginosa via the pyoverdin-mediated iron uptake pathway [J] . Kinzel O., Gerus I., Budzikiewicz H., The Journal of Antibiotics: An International Journal . 1998,第5期

机译：两种通过泛素介导的铁吸收途径进入铜绿假单胞菌的泛素-氨苄青霉素结合物的合成和抑菌活性
4. Studies of Bacterial of Iron Uptake and Release by Hydrogen/Deuterium Exchange [C] . Leslie P. Silva, Xue Yang, Rong-hua Yu, American Society for Mass Spectrometry Conference on Mass Spectrometry and Allied Topics . 2011

机译：氢气/氘交换的铁吸收细菌的研究
5. Elucidating unique iron uptake pathways by an environmental bacterium, Rhizobium sp. strain TAL1145. [D] . Vicente, Davin J. 2012

机译：阐明环境细菌根瘤菌独特的铁吸收途径。菌株TAL1145。
6. Modes of action and inhibitory activities of new siderophore-beta-lactam conjugates that use specific iron uptake pathways for entry into bacteria. [O] . A Brochu, N Brochu, T I Nicas, 1992

机译：使用特定铁吸收途径进入细菌的新型铁载体-β-内酰胺结合物的作用方式和抑制活性。
7. Bacterial Iron Uptake Pathways: Gates for the Import of Bactericide Compounds [O] . Isabelle J. Schalk, Gaëtan L. A. Mislin 2017

机译：细菌铁摄取途径：用于进口杀菌化合物的栅极

Bacterial Iron Uptake Pathways: Gates for the Import of Bactericide Compounds

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