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首页> 外文期刊>Journal of Molecular Liquids >Apical-basal polarity of epithelial cells imaged by Raman microscopy and Raman imaging: Capabilities and challenges for cancer research
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Apical-basal polarity of epithelial cells imaged by Raman microscopy and Raman imaging: Capabilities and challenges for cancer research

机译：由拉曼显微镜和拉曼成像成像的上皮细胞的顶部基础极性：癌症研究的能力和挑战

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AbstractThe common feature of cells is their polarity which refers to cellular asymmetry that reflects the asymmetric organization of the cell including the cell surface, intracellular organelles and the cytoskeleton. Cell polarity is a major regulatory mechanism for controlling spatially restricted signaling, reorganization of the cytoskeleton, and polarized membrane trafficking.The common feature of cancer development is the increased loss of cell polarity that results in epithelial tissue disorganization. Despite intense interest in determining the origin of tumor tissue disorganization, the function of cell polarity remains unclear. In the study we traced the epithelial cell asymmetry and concentration gradient of main constituents of the cells along the apical-basal axis and monitored ordering of the duct at the apical region compared to basal region in normal and cancerous human breast duct. The results obtained in this paper reveal that the normal duct is polarized with asymmetric distribution of lipids, proteins, carotenoids, triglycerides and that an inverse situation occurred in duct that lost apical polarity upon cancer development. This study shows that in epithelial tissue, the individual epithelial cells are split into two regions, the apical and basolateral regions, which are chemically and structurally different from each other. The apical region of the normal duct is rich in unsaturated triglycerides derived from oleic acid (glyceryl trioleate), carotenoids and proteins. The concentration of these chemical components decreases along the apical-basal axis. The radial distribution functions of concentration
机译：<！[cdata [ 抽象 单元格的公共特征是它们的极性，这是指反映包括该单元的不对称组织的蜂窝不对称的极性。细胞表面，细胞内细胞器和细胞骨架。细胞极性是用于控制空间限制信号，细胞骨架的重组和偏振膜运输的主要调节机制。 常见癌症发展的特征是导致上皮组织紊乱的细胞极性丧失增加。尽管对确定肿瘤组织混乱的起源感兴趣，但细胞极性的功能仍然不清楚。在该研究中，我们将细胞的主要成分沿着顶端轴线追踪细胞的主要成分，并与正常和癌症的人乳房管道中的基底区域相比监测管道的排序。本文中获得的结果表明，正常管道与脂质，蛋白质，类胡萝卜素，甘油三酯的不对称分布偏振，导管发生在癌症发育时发生的管道逆情况。该研究表明，在上皮组织中，个体上皮细胞被分成两个区域，顶端和基石区域，其在化学上和结构上彼此不同。正常管道的顶端区域富含不饱和甘油三酯，衍生自油酸（甘油三糖酸酯），类胡萝卜素和蛋白质。这些化学成分的浓度沿着顶端基底轴减小。浓度的径向分布功能

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