• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of Molecular Biology >Cytoskeletal Control of Nuclear Morphology and Chromatin Organization
【24h】

Cytoskeletal Control of Nuclear Morphology and Chromatin Organization

机译：核形态学和染色质组织的细胞骨骼控制

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The nucleus is sculpted toward various morphologies during cellular differentiation and development. Alterations in nuclear shape often result in changes to chromatin organization and genome function. This is thought to be reflective of its role as a cellular mechanotransducer. Recent evidence has highlighted the importance of cytoskeletal organization in defining how nuclear morphology regulates chromatin dynamics. However, the mechanisms underlying cytoskeletal control of chromatin remodeling are not well understood. We demonstrate here the differential influence of perinuclear actin- and microtubule-driven assemblies on nuclear architecture using pharmacological inhibitors and targeted RNA interference knockdown of cytoskeleton components in Drosophila cells. We find evidence that the loss of perinuclear actin assembly results in basolateral enhancement of microtubule organization and this is reflected functionally by enhanced nuclear dynamics. Cytoskeleton reorganization leads to nuclear lamina deformation that influences heterochromatin localization and core histone protein mobility. We also show that modulations in actin microtubule assembly result in differential gene expression patterns. Taken together, we suggest that perinuclear actin and basolateral microtubule organization exerts mechanical control on nuclear morphology and chromatin dynamics. (c) 2014 Elsevier Ltd. All rights reserved.
机译：在细胞分化和发育期间，核朝向各种形态雕刻。核形状的改变通常导致染色质组织和基因组功能的变化。这被认为是反映其作为一种细胞机械助理的作用。最近的证据强调了细胞骨骼组织在定义核形态学如何调节染色质动力学的重要性。然而，染色质重塑的细胞骨骼控制的潜在机制尚不清楚。这里展示了使用药理学抑制剂和靶向RNA细胞组分在果蝇细胞中的核架构对核架构对核架构的差异影响。我们发现证据表明，PerinuclectActin组件的丧失导致基底外侧增强微管组织，这通过增强的核动力学来反映。细胞骨架重组导致核薄层变形，其影响异铬胺定位和核心组蛋白迁移率。我们还表明，肌动蛋白微管组件的调节导致差异基因表达模式。我们携带在一起，我们建议Perinuclect actin和基石外微管组织对核形态和染色质动力学进行机械控制。 （c）2014年elestvier有限公司保留所有权利。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号