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Regulation of Mitochondria! Electron Transport Chain Assembly

机译:监管线粒体! 电子传输链组件

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Mitochondrial function depends on the correct synthesis, transport, and assembly of proteins and cofactors of the electron transport chain. The initial idea that the respiratory chain protein complexes (RCCs) were independent structures in the inner mitochondrial membrane evolved after the identification of higher quaternary structures called supercomplexes (SCs), whose formation is dynamically regulated in order to accommodate cellular metabolic demands. Due to the dual genetic origin of the mitochondril proteome, electron transport chain and SCs formation must be tightly regulated to coordinate the expression and assembly of components encoded by both genomes. This regulation occurs at different levels from gene transcription to protein, complex or SCs assembly, and might involve the participation of factors that contribute to the formation and stability of the RCCs and SCs. Here we review the cellular pathways and assembly factors that regulate RCCs and SCs formation. (C) 2018 Elsevier Ltd. All rights reserved.
机译:线粒体功能取决于电子传输链的蛋白质和辅助件的正确合成,运输和组装。呼吸链蛋白复合物(RCC)在内部线粒体膜中的初始构造是在鉴定称为超复用(SCS)的较高季结构之后演化的内部线粒体膜中的独立结构,其形成是为了适应细胞代谢要求。由于线粒体蛋白质组的双重遗传来源,必须紧密调节电子传输链和SCS形成,以协调两个基因组编码的组分的表达和组装。该调节发生在与基因转录到蛋白质,复合物或SCS组件的不同水平,并且可能涉及参与导致RCC和SCS的形成和稳定性的因素。在这里,我们审查了调节RCC和SCS形成的细胞途径和装配因素。 (c)2018年elestvier有限公司保留所有权利。

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