Molecular Insights into the Architecture of the Human SMC5/6 Complex

Adamus M.; Lelkes E.; Potesil D.; Ganji S. R.; Kolesar P.; Zabrady K.; Zdrahal Z.; Palecek J. J.

首页> 外文期刊>Journal of Molecular Biology >Molecular Insights into the Architecture of the Human SMC5/6 Complex

【24h】

Molecular Insights into the Architecture of the Human SMC5/6 Complex

机译：分子见解进入人类SMC5 / 6复合物的架构

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

A family of Structural Maintenance of Chromosome (SMC) complexes is essential for key cellular processes ensuring proper cohesion, condensation and replication. They share a common SMC-kleisin architecture allowing them to embrace DNA. In SMC5/6, the NSE1 and NSE3 KITE and NSE4 kleisin subunits form a stable subcomplex that binds DNA and regulates essential processes. In addition, NSE5 and NSE6 subunits associate with the core SMC5/6 complex and recruit it to DNA repair sites.

机译：染色体（SMC）复合物的结构维持系列对于重点细胞过程至关重要，确保适当的内聚力，缩合和复制。它们共享一个常见的SMC-Kleisin架构，允许他们拥抱DNA。在SMC5 / 6中，NSE1和NSE3 KITE和NSE4 Kleisin亚基形成稳定的子拷贝，结合DNA并调节必要过程。此外，NSE5和NSE6亚基与核心SMC5 / 6复合物联系起来，并将其招募到DNA修复位点。

著录项

来源
《Journal of Molecular Biology》 |2020年第13期|共18页
作者
Adamus M.; Lelkes E.; Potesil D.; Ganji S. R.; Kolesar P.; Zabrady K.; Zdrahal Z.; Palecek J. J.;
展开▼
作者单位

Masaryk Univ Mendel Ctr Plant Genom &

Prote Cent European Inst Technol Kamenice 5 Brno 62500;

Masaryk Univ Fac Sci Natl Ctr Biomol Res Kotlarska 2 Brno 61137 Czech Republic;

Masaryk Univ Mendel Ctr Plant Genom &

Prote Cent European Inst Technol Kamenice 5 Brno 62500;

Masaryk Univ Mendel Ctr Plant Genom &

Prote Cent European Inst Technol Kamenice 5 Brno 62500;

Masaryk Univ Fac Sci Natl Ctr Biomol Res Kotlarska 2 Brno 61137 Czech Republic;

Masaryk Univ Fac Sci Natl Ctr Biomol Res Kotlarska 2 Brno 61137 Czech Republic;

Masaryk Univ Mendel Ctr Plant Genom &

Prote Cent European Inst Technol Kamenice 5 Brno 62500;

Masaryk Univ Mendel Ctr Plant Genom &

Prote Cent European Inst Technol Kamenice 5 Brno 62500;

展开▼
收录信息
原文格式 PDF
正文语种 eng
中图分类分子生物学;
关键词
human SMC5/6 complex architecture; SMC5-SMC6 dimer coiled-coil arms; NSE1-NSE3-NSE4 trimer; NSE5-NSE6 dimer; CANIN protein-protein interaction domain; MAGE domain;

机译：人类SMC5 / 6复杂架构;SMC5-SMC6二聚体卷轴臂;NSE1-NSE3-NSE4三聚体;NSE5-NSE6二聚体;甘蛋白 - 蛋白质相互作用域;法师域;

相似文献

外文文献
中文文献
专利

1. Molecular Insights into the Architecture of the Human SMC5/6 Complex [J] . Adamus M., Lelkes E., Potesil D., Journal of Molecular Biology . 2020,第13期

机译：分子见解进入人类SMC5 / 6复合物的架构
2. Structures of SPOP-substrate complexes: insights into molecular architectures of BTB-Cul3 ubiquitin ligases. [J] . Zhuang M, Calabrese MF, Liu J, Molecular cell . 2009,第1期

机译：SPOP底物复合物的结构：深入了解BTB-Cul3泛素连接酶的分子结构。
3. Molecular architecture of the human sinus node: insights into the function of the cardiac pacemaker. [J] . Chandler NJ, Greener ID, Tellez JO, Circulation: An Official Journal of the American Heart Association . 2009,第12期

机译：人类窦房结的分子结构：深入了解心脏起搏器的功能。
4. Insights into the Interaction Energy for Cs~+-Crown Ether complex by Molecular Dynamics Simulations [C] . Rima Biswas, Pallab Ghosh, Sk. Musharaf Ali International Conference on Advances in Energy Research . 2017

机译：通过分子动力学模拟对CS〜+ -CherRown醚复合体的相互作用能量见解
5. The molecular architecture of human transcription-coupled DNA repair complexes. [D] . Kostek, Seth Anthony. 2005

机译：人类转录偶联的DNA修复复合物的分子结构。
6. How and why plants and human N-glycans are different: Insight from molecular dynamics into the glycoblocks architecture of complex carbohydrates [O] . Carl A Fogarty, Aoife M Harbison, Amy R Dugdale, 2020

机译：植物和人n-glycans如何以及为何是不同的：从分子动力学到甘油块的复合碳水化合物结构中的洞察力
7. How and why plants and human N-glycans are different: Insight from molecular dynamics into the “glycoblocks” architecture of complex carbohydrates [O] . CA Fogarty, AM Harbison, AR Dugdale, 2020

机译：植物和人n-glycans如何以及为何是不同的：从分子动力学到“甘油块”的复合碳水化合物结构中的洞察力

Molecular Insights into the Architecture of the Human SMC5/6 Complex

摘要

著录项

相似文献

相关主题

期刊订阅