An Interspecies Analysis Reveals Molecular Construction Principles of Interleukin 27

Mueller Stephanie I.; Aschenbrenner Isabel; Zacharias Martin; Feige Matthias J.

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An Interspecies Analysis Reveals Molecular Construction Principles of Interleukin 27

机译：Interspecies分析显示白细胞介素27的分子构建原理

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Interleukin 27 (IL-27) is a cytokine that regulates inflammatory responses. It is composed of an a subunit (IL-27 alpha) and a beta subunit (EBI3), which together form heterodimeric IL-27. Despite this general principle, IL-27 from different species shows distinct characteristics: Human IL-27 alpha is not secreted autonomously while EBI3 is. In mice, the subunits show a reciprocal behavior. The molecular basis and the evolutionary conservation of these differences have remained unclear. They are biologically important, however, since secreted IL-27 subunits can act as cytokines on their own.

机译：白细胞介素27（IL-27）是一种调节炎症反应的细胞因子。它由亚基（IL-27α）和β亚基（EBI3）组成，其一起形成异二聚体IL-27。尽管这一般原则，来自不同物种的IL-27显示出明显的特征：人体IL-27 alpha没有自主分泌，而ebi3是。在小鼠中，亚基显示互惠行为。分子基础和这些差异的进化守恒仍然不清楚。然而，它们是生物学上重要的，因为分泌的IL-27亚基可以独自充当细胞因子。

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来源
《Journal of Molecular Biology》 |2019年第12期|共11页
作者
Mueller Stephanie I.; Aschenbrenner Isabel; Zacharias Martin; Feige Matthias J.;
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作者单位

Tech Univ Munich Ctr Integrated Prot Sci Dept Chem D-85748 Garching Germany;

Tech Univ Munich Ctr Integrated Prot Sci Dept Chem D-85748 Garching Germany;

Tech Univ Munich Dept Phys Ctr Integrated Prot Sci D-85748 Garching Germany;

Tech Univ Munich Ctr Integrated Prot Sci Dept Chem D-85748 Garching Germany;

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原文格式 PDF
正文语种 eng
中图分类分子生物学;
关键词
Interleukins; Protein assembly; Protein docking; Protein evolution;

机译：白细胞介素;蛋白质组装;蛋白质对接;蛋白质演变;

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1. An Interspecies Analysis Reveals Molecular Construction Principles of Interleukin 27 [J] . Mueller Stephanie I., Aschenbrenner Isabel, Zacharias Martin, Journal of Molecular Biology . 2019,第12期

机译：Interspecies分析显示白细胞介素27的分子构建原理
2. Molecular analysis of myelodysplastic syndrome with isolated deletion of the long arm of chromosome 5 reveals a specific spectrum of molecular mutations with prognostic impact: a study on 123 patients and 27 genes [J] . Manja Meggendorfer, Claudia Haferlach, Wolfgang Kern, Haematologica . 2017,第9期

机译：骨髓增生异常综合症的分子分析与5号染色体长臂的孤立缺失揭示了具有预后影响的特定分子突变谱：一项针对123位患者和27个基因的研究
3. Molecular and ultrastructural analysis of forisome subunits reveals the principles of forisome assembly [J] . Mueller Boje, Groscurth Sira, Menzel Matthias, Annals of Botany . 2014,第7期

机译：分子亚单位的分子和超微结构分析揭示了分子组装的原理
4. Metabolic Interspecies Comparison Using LC/MS and Principle Component Analysis [C] . Tania A. Sasaki, Robert Cho, Claire J. Bramwell, ASMS Conference on Mass Spectrometry and Allied Topics . 2008

机译：使用LC / MS和主成分分析的代谢差异比较
5. The protective role of fat specific protein 27 (FSP27) against Interleukin-1 beta and Interleukin-6 induced lipolysis and insulin resistance in human adipocytes [D] . Delio, Melissa Caitlin 2015

机译：脂肪特异性蛋白27（FSP27）对白细胞介素-1β和白细胞介素-6诱导人类脂肪细胞诱导脂解和胰岛素抗性的保护作用
6. Molecular and ultrastructural analysis of forisome subunits reveals the principles of forisome assembly [O] . Boje Müller, Sira Groscurth, Matthias Menzel, 2014

机译：分子亚单位的分子和超微结构分析揭示了分子组装的原理
7. Computational analysis of four human adenovirus type 4 genomes reveals molecular evolution through two interspecies recombination events [O] . Dehghan Shoaleh, Seto Jason, Liu Elizabeth B., 2013

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An Interspecies Analysis Reveals Molecular Construction Principles of Interleukin 27

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