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首页> 外文期刊>Journal of Neurochemistry: Offical Journal of the International Society for Neurochemistry >Differential serotonin transporter (5‐HTT) and 5‐HT 2 2 receptor density in limbic and neocortical areas of adults and children with autism spectrum disorders: implications for selective serotonin reuptake inhibitor efficacy
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Differential serotonin transporter (5‐HTT) and 5‐HT 2 2 receptor density in limbic and neocortical areas of adults and children with autism spectrum disorders: implications for selective serotonin reuptake inhibitor efficacy

机译：差分性血清素转运蛋白（5-HTT）和5-HT 2 2肢体和患有自闭症谱系疾病儿童的Neocortical地区的5-HT 2 2受体密度：对选择性血清素再摄取抑制剂功效的影响

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Abstract As selective serotonin reuptake inhibitors (SSRIs) are among the most commonly prescribed medications in autism, we aimed to determine whether targets for SSRIs are differentially affected in three cortical areas in children and adults with autism compared to neurotypical individuals. Utilizing a large cohort of postmortem brain tissue ( n ?=?14–19 per group), saturation ligand binding assays were conducted on sections from the anterior cingulate cortex (ACC), posterior cingulate cortex, and fusiform gyrus (FG). Specific binding to the 5‐HT transporter (5‐HTT) as well as to 5‐HT2 and 1A receptors (5‐HT?, 5‐HT 1A ) was quantified in superficial and deep layers of each region using the ligands [ 3 H]‐citalopram (5‐HTT), [ 3 H]‐ketanserin (5‐HT 2 ), and [ 3 H]‐8‐OH‐DPAT (5‐HT 1A ). A Welch’s t ‐test was utilized to compare receptor densities ( B max ), revealing a statistically significant decrease in 5‐HTT within the ACC of the entire autism cohort. There was also a decrease in 5‐HT 2 receptor density in the ACC in the adult cohort, but not in child postmortem autism cases as compared to controls. Comparing linear regression lines of B max values plotted against age, shows a significantly lower intercept for 5‐HTT in autism ( p ?=?0.025). 5‐HT? density increases with age in control cases, whereas in autism there is a decrease with age and significantly different slopes between regression lines ( p ?=?0.032). This suggests a deficit in 5‐HTT within the ACC in individuals with autism, while decreases in 5‐HT? density are age‐dependent. There were no differences in receptor densities in the posterior cingulate cortex or FG in autism and no differences in ligand affinity ( K D ) across all regions and ligands examined.
机译：摘要随着选择性血清素再摄取抑制剂（SSRIS）是最常见的自闭症中最常见的药物，我们旨在确定SSRIS的靶标在儿童和成人中的三种皮质区域是否与神经典型的个体相比，患有神经疾病的三种皮质区域。利用大队列的后脑脑组织（每组N？= 14-19），在前铰接皮质（ACC），后铰链皮质和梭形转象（FG）的部分上进行饱和配体结合测定。使用配体的每个区域的浅表和深层定量与5-HT转运蛋白（5-HTT）以及5-HT2和5-HT 1A）的特定结合[3小时] -CitalOPRAM（5-HTT），[3 H] - 酮蛋白（5-HT 2），[3 H] -8-OH-DPAT（5-HT 1A）。韦尔奇的T -Test用于比较受体密度（B MAX），揭示整个自闭症队列的ACC内的5-HTT的统计学显着降低。成人队列中的ACC中的5-HT 2受体密度也有降低，但与对照相比，儿童后期自闭症病例。比较B最大值的线性回归线绘制的AGE，在自闭症中的5-HTT显着降低截距（P？= 0.025）。 5-HT？密度随着控制病例的年龄而增加，而在自闭症中，随着年龄的增长和回归线之间的斜率显着下降（P？= 0.032）。这表明在自闭症中的个人内部的5-HTT内的赤字，而5-HT中的减少？密度依赖于年龄。后刺铰霉菌型皮质或术中的FG中的受体密度没有差异，并且在所有区域和配体中没有配体亲和力（K d）的差异。

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