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首页> 外文期刊>Journal of Neurophysiology >Mechanical coupling through the skin affects whisker movements and tactile information encoding
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Mechanical coupling through the skin affects whisker movements and tactile information encoding

机译：通过皮肤的机械耦合会影响晶须运动和触觉信息编码

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Rats use their whiskers to extract sensory information from their environment. While exploring, they analyze peripheral stimuli distributed over several whiskers. Previous studies have reported cross-whisker integration of information at several levels of the neuronal pathways from whisker follicles to the somatosensory cortex. In the present study, we investigated the possible coupling between whiskers at a preneuronal level, transmitted by the skin and muscles between follicles. First, we quantified the movement induced on one whisker by deflecting another whisker. Our results show significant mechanical coupling, predominantly when a given whisker's caudal neighbor in the same row is deflected. The magnitude of the effect was correlated with the diameter of the deflected whisker. In addition to changes in whisker angle, we observed curvature changes when the whisker shaft was constrained distally from the base. Second, we found that trigeminal ganglion neurons innervating a given whisker follicle fire action potentials in response to high-magnitude deflections of an adjacent whisker. This functional coupling also shows a bias toward the caudal neighbor located in the same row. Finally, we designed a two-whisker biomechanical model to investigate transmission of forces across follicles. Analysis of the whisker-follicle contact forces suggests that activation of mechanoreceptors in the ring sinus region could account for our electrophysiological results. The model can fully explain the observed caudal bias by the gradient in whisker diameter, with possible contribution of the intrinsic muscles connecting follicles. Overall, our study demonstrates the functional relevance of mechanical coupling on early information processing in the whisker system.
机译：大鼠使用他们的晶须从他们的环境中提取感官信息。在探索时，他们分析了分布在几个晶须的外周刺激。以前的研究报告了从晶须泡孔到躯体感染术的神经元途径的几个水平的交叉晶须整合。在本研究中，我们研究了晶须在小核水平之间的可能耦合，由皮肤和卵泡之间的肌肉传递。首先，我们通过偏转另一个晶须量化在一个晶须上引起的运动。我们的结果显示出显着的机械耦合，主要是当给定的晶须在同一行中的尾部邻接被偏转时。效果的幅度与偏转晶须的直径相关。除了晶须角度的变化之外，当晶须轴从底座上远侧约束时，我们观察到曲率变化。其次，我们发现三叉神经节神经元响应于相邻晶须的高幅度偏转，在给定的晶须卵须释放动作电位。该功能耦合还示出了位于同一行中的尾邻的偏压。最后，我们设计了一个双晶须生物力学模型，以调查跨卵泡的力传播。晶须 - 卵卷接触力的分析表明，环形窦区域中力学器的激活可以解释我们的电生理结果。该模型可以通过晶须直径的梯度完全解释观察到的尾偏压，具有连接卵泡的固有肌肉的可能贡献。总体而言，我们的研究表明了机械耦合对晶须系统早期信息处理的功能相关性。

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