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首页> 外文期刊>Journal of Neurophysiology >Differential effects of aging and physical activity on corticospinal excitability of upper and lower limb muscles
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Differential effects of aging and physical activity on corticospinal excitability of upper and lower limb muscles

机译：老化和身体活性对上下肢体皮质兴奋性的差异影响

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Corticospinal tract excitability can be altered by age, physical activity (PA), and possibly sex, but whether these effects differ between upper and lower limb muscles is unknown. We determined the influence of age, PA, and sex on corticospinal excitability of an upper limb and a lower limb muscle during submaximal contractions by comparing stimulus-response curves of motor evoked potentials (MEPs). Transcranial magnetic stimulation (TMS) was used to evoke stimulus-response curves in active muscles by incrementally increasing the stimulator intensity from below the active motor threshold (AMT) until a plateau in MEP amplitudes was achieved. Stimulus-response curves were analyzed from the first dorsal interosseous (FDI) of 30 young (23.9 +/- 3.8 yr) and 33 older (72.6 +/- 5.6 yr) men and women and the vastus lateralis (VL) of 13 young (23.2 +/- 2.2 yr) and 25 older (72.7 +/- 5.5 yr) men and women. Corticospinal excitability was determined by fitting the curves with a four-parameter sigmoidal curve and calculating the maximal slope (slope (max)). PA was assessed with triaxial accelerometry. and participants were dichotomized into high-PA (>10,000 steps/day, n = 15) or low-PA ( 0.05). VL MEP amplitudes and slope(max), however, were lower in the high-PA than low-PA participants, with no age or sex differences. These data suggest that aging and PA, but not sex, differentially influence the excitability of the corticospinal tracts projecting to muscles of the upper compared with the lower limb.
机译：皮质脊髓诱导性可以通过年龄，身体活动（PA）和可能性发生性别，但这些效应是否在上肢和下肢肌肉之间存在不同。通过比较电动机诱发电位（MEP）的刺激响应曲线，我们确定年龄，Pa和性别对上肢的皮质痉挛和下肢肌肉的影响和下肢肌肉的影响。通过逐渐增加从活性电动机阈值（AMT）以下刺激器强度直到实现MEP振幅的平台，通过逐渐增加刺激态磁刺激（TMS）来唤起活性肌肉中的刺激响应曲线。从30名年轻（23.9 +/- 3.8 YR）和33名男性和女性的33名（72.6 +/- 5.6 YR）和13名年轻人（vl）的33名较年轻的（72.6 +/- 5.6岁）分析刺激 - 反应曲线。 23.2 +/- 2.2 yr）和25岁（72.7 +/- 5.5岁）男女。通过用四个参数六样曲线拟合曲线并计算最大斜率（斜率（最多））来确定皮质旋流性。通过三轴加速度评估PA。和参与者分为高PA（> 10,000步/天，N = 15）或低PA（0.05）。然而，VL MEP幅度和斜坡（最大值）比低PA参与者低，没有年龄或性别差异。这些数据表明，老化和PA，但性别而不是性，差异地影响了与下肢相比较高的皮质脊髓狭窄的兴奋性。

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