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首页> 外文期刊>Journal of Neurophysiology >Doxapram stimulates respiratory activity through distinct activation of neurons in the nucleus hypoglossus and the pre-Botzinger complex
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Doxapram stimulates respiratory activity through distinct activation of neurons in the nucleus hypoglossus and the pre-Botzinger complex

机译：Doxapram通过在核心腺嘧啶和前痘痘复合物中的神经元不同的神经元激活来刺激呼吸系统活性

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摘要

Doxapram is a respiratory stimulant used for decades as a treatment option in apnea of prematurity refractory to methylxanthine treatment. Its mode of action, however, is still poorly understood. We investigated direct effects of doxapram on the pre-Botzinger complex (PreBotC) and on a downstream motor output system, the hypoglossal nucleus (XII), in the transverse brain-stem slice preparation. While doxapram has only a modest stimulatory effect on frequency of activity generated within the PreBotC, a much more robust increase in the amplitude of population activity in the subsequent motor output generated in the XII was observed. In whole cell patch-clamp recordings of PreBotC and XII neurons, we confirmed significantly increased firing of evoked action potentials in XII neurons in the presence of doxapram, while PreBotC neurons showed no significant alteration in firing properties. Interestingly, the amplitude of activity in the motor output was not increased in the presence of doxapram compared with control conditions during hypoxia. We conclude that part of the stimulatory effects of doxapram is caused by direct input on brainstem centers with differential effects on the rhythm generating kernel (PreBotC) and the downstream motor output (XII).
机译：Doxapram是一种呼吸兴奋剂，几十年作为呼吸呼吸暂停治疗的呼吸暂停治疗的治疗选择。然而，它的行动方式仍然很差。我们在横向脑干切片制剂中调查了Doxapram对Botzinger复合物（PROBOTC）和下游电动机输出系统的直接影响，在横向脑干切片制剂中。虽然Doxapram仅对PROBOTC中产生的活动频率仅具有适度刺激的刺激作用，但观察到在XII中产生的随后的电动机输出中的群体活动幅度更大增加。在PRBOTC和XII神经元的全细胞膜片夹具中，我们在DOXAPRAM存在下证实了在XII神经元的诱发动作电位射击的显着增加，而PREBOTC神经元显示出烧制性能显着改变。有趣的是，与缺氧期间的对照条件相比，在Doxapram存在下，电动机输出中的活性幅度不会增加。我们得出结论，Doxapram的刺激效果部分是由直接输入脑干中心对节奏产生核（PROBOTC）和下游电动机输出（XII）的差异影响引起的。

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