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首页> 外文期刊>Journal of Neurophysiology >Dentate spikes and learning: disrupting hippocampal function during memory consolidation can improve pattern separation
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Dentate spikes and learning: disrupting hippocampal function during memory consolidation can improve pattern separation

机译：牙齿尖峰和学习：在记忆整合期间扰乱海马功能可以改善模式分离

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Hippocampal dentate spikes (DSs) are short-duration, large-amplitude fluctuations in hilar local field potentials and take place while resting and sleeping. During DSs, dentate gyms granule cells increase firing while CA1 pyramidal cells decrease firing. Recent findings suggest DSs play a significant role in memory consolidation after training on a hippocampus-dependent, nonspatial associative learning task. Here, we aimed to find out whether DSs are important in other types of hippocampus-dependent learning tasks as well. To this end, we trained adult male Sprague-Dawley rats in a spatial reference memory task, a fixed interval task, and a pattern separation task. During a rest period immediately after each training session, we either let neural activity to take place as usual, timed electrical stimulation of the ventral hippocampal commissure (vHC) to immediately follow DSs, or applied the vHC stimulation during a random neural state. We found no effect of vHC stimulation on performance in the spatial reference memory task or in the fixed interval task. Surprisingly, vHC stimulation, especially contingent on DSs, improved performance in the pattern separation task. In conclusion, the behavioral relevance of hippocampal processing and DSs seems to depend on the task at hand. It could be that in an intact brain, offline memory consolidation by default involves associating neural representations of temporally separate but related events. In some cases this might be beneficial for adaptive behavior in the future (associative learning), while in other cases it might not (pattern separation).
机译：海马牙齿尖峰（DSS）是亨伦特局部潜力的短时间，大幅度波动，并在休息和睡觉时进行。在DSS期间，牙齿健身房颗粒细胞增加烧制，而CA1金字塔细胞减少烧制。最近的发现表明DSS在依赖海马依赖的非私人协会学习任务的培训后在内存整合中发挥着重要作用。在这里，我们旨在了解DSS是否在其他类型的海马依赖学习任务中是重要的。为此，我们在空间参考记忆任务，固定间隔任务和模式分离任务中培训了成年男性Sprague-Dawley大鼠。在每次训练会议后立即休息期间，我们要么让神经活动发生，以便通常发生腹侧海马通道（VHC）的定时电刺激，以立即遵循DSS，或在随机神经状态期间施加VHC刺激。我们发现VHC刺激对空间参考存储器任务或固定间隔任务中的性能的影响。令人惊讶的是，VHC刺激，特别是在DSS上或目前，在模式分离任务中提高了性能。总之，海马处理和DSS的行为相关性似乎取决于手头的任务。在完整的大脑中，默认情况下，离线内存合并涉及将神经表示与时间分离但相关事件相关联。在某些情况下，这可能对未来（关联学习）的自适应行为有益，而在其他情况下，它可能不会（模式分离）。

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