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首页> 外文期刊>Journal of Neurophysiology >Single and population coding of taste in the gustatory cortex of awake mice
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Single and population coding of taste in the gustatory cortex of awake mice

机译：令人瞩目的味觉皮层中的单身和人口编码

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Electrophysiological analysis has revealed much about the broad coding and neural ensemble dynamics that characterize gustatory cortical (GC) taste processing in awake rats and about how these dynamics relate to behavior. With regard to mice, however, data concerning cortical taste coding have largely been restricted to imaging, a technique that reveals average levels of neural responsiveness but that (currently) lacks the temporal sensitivity necessary for evaluation of fast response dynamics; furthermore, the few extant studies have thus far failed to provide consensus on basic features of coding. We have recorded the spiking activity of ensembles of GC neurons while presenting representatives of the basic taste modalities (sweet, salty, sour, and bitter) to awake mice. Our first central result is the identification of similarities between rat and mouse taste processing: most mouse GC neurons (similar to 66%) responded distinctly to multiple (3-4) tastes; temporal coding analyses further reveal, for the first time, that single mouse GC neurons sequentially code taste identity and palatability, the latter responses emerging similar to 0.5 s after the former, with whole GC ensembles transitioning suddenly and coherently from coding taste identity to coding taste palatability. The second finding is that spatial location plays very little role in any aspect of taste responses: neither between(anterior-posterior) nor within-mouse (dorsal-ventral) mapping revealed anatomic regions with narrow or temporally simple taste responses. These data confirm recent results showing that mouse cortical taste responses are not "gustotopic" but also go beyond these imaging results to show that mice process tastes through time.
机译：电生理学分析揭示了令人讨厌的味觉皮质（GC）味觉处理的广泛编码和神经集合动态的大大揭示了许多关于唤醒大鼠的味觉处理以及这些动态如何与行为有关。然而，关于小鼠的数据，关于皮质味道编码的数据在很大程度上仅限于成像，这是一种揭示神经响应性平均水平的技术，但（目前）缺乏评估快速响应动态所需的时间灵敏度;此外，迄今为止，少数现存研究未能在编码的基本特征上提供共识。我们已经录制了GC神经元的集合的尖峰活动，同时提出了唤醒小鼠的基本味道型（甜，咸，酸和苦）的代表。我们的第一中心结果是鉴定大鼠和小鼠味道处理之间的相似性：大多数小鼠GC神经元（类似于66％）明显响应多（3-4）口味;颞下编码分析进一步揭示单鼠GC神经元顺序代码的味道身份和适口性，后者响应在前者之后出现类似于0.5秒，整个GC集合从编码味道身份中突然和连贯过渡到编码味道适度。第二个发现是空间位置在味道反应的任何方面发挥着作用很小：既不与小鼠内（背侧 - 腹侧）映射都没有显示具有狭窄或时间简单味道反应的解剖区域。这些数据确认最近的结果表明，鼠标皮质味道反应不是“偶然的”，而且还超出了这些成像结果，以表明小鼠过程味道通过时间。

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