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首页> 外文期刊>Journal of Neurophysiology >Microstructural integrity of corticospinal and medial lemniscus tracts: insights from diffusion tensor tractography of right-hand amputees
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Microstructural integrity of corticospinal and medial lemniscus tracts: insights from diffusion tensor tractography of right-hand amputees

机译：皮质柱和内侧局域网的微观结构完整性：右手急性扩散张量牵引的见解

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摘要

Reductions in sensory and motor activity following unilateral upper limb amputation during adulthood are associated with widespread, activity-dependent reorganization of the gray matter and white matter through the central nervous system. Likewise, in cases of congenital limb absence there is evidence that limited afferent or efferent activity affects the structural integrity of white matter pathways serving the affected side. Evidence that the structural integrity of mature sensory and motor tracts controlling the lost upper limb exhibits similar activity dependence is, however, sparse and inconsistent. Here we used diffusion tensor tractography to test whether amputation of the dominant right hand during adulthood (n = 16) alters the microstructural integrity of the major sensory (medial lemniscus, ML) and motor (corticospinal tract, CST) pathways controlling missing hand function. Consistent with prior findings, healthy control subjects (n = 27) exhibited higher fractional anisotropy (FA). an index of white matter microstructural integrity, within dominant left CST and nondominant right ML. Critically, in contrast to what might be expected if the microstructural organization of these tracts is activity dependent, these asymmetries persisted in amputees. Moreover, we failed to detect any differences in dominant left ML or CST between healthy control subjects and amputees. Our results are consistent with these white matter tracts being robust to changes in activity once mature or that continued use of the residual limb (in a compensatory fashion or with prosthesis) provides stimulation sufficient to maintain tract integrity.
机译：在成年期间单侧上肢截肢后的感觉和电机活动的减少与通过中枢神经系统的灰质和白质依赖于广泛，活性依赖性重组相关。同样，在先天性肢体缺失的情况下，有有限的传入或传动活动影响了受影响侧的白质途径的结构完整性。证据表明，控制失落的上肢的成熟感官和电动机的结构完整性表现出类似的活性依赖性，然而，稀疏和不一致。在这里，我们使用扩散张量牵引试验在成年期（n = 16）期间的显性右手的截肢是否改变了主要感官（内侧Lemniscus，Ml）和电机（皮质脊髓源，CST）途径控制缺失的手函数的微观结构完整性。与现有结果一致，健康对照受试者（n = 27）表现出更高的分数各向异性（FA）。白质微观结构完整性指数，在优势左侧CST和Nondominant右ML。批判性地，与可能预期的依赖于活性的微观组织组织依赖的情况相反，这些不对称的持续存在于随意中。此外，我们未能检测健康对照受试者与患者之间的左ML或CST的任何差异。我们的结果与这些白质散布稳健一致，以一旦成熟或继续使用残留肢体（以补偿时尚或假体）提供足以维持道完整性的刺激。

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