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首页> 外文期刊>Journal of Neurophysiology >Visual responses in the dorsal lateral geniculate nucleus at early stages of retinal degeneration in rd(1) PDE6 beta mice
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Visual responses in the dorsal lateral geniculate nucleus at early stages of retinal degeneration in rd(1) PDE6 beta mice

机译：在RD（1）PDE6β小鼠的视网膜退化早期背侧突出核的视觉响应

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Inherited retinal degenerations encompass a wide range of diseases that result in the death of rod and cone photoreceptors, eventually leading to irreversible blindness. Low vision survives at early stages of degeneration, at which point it could rely on residual populations of rod/cone photoreceptors as well as the inner retinal photoreceptor, melanopsin. To date, the impact of partial retinal degeneration on visual responses in the primary visual thalamus (dorsal lateral geniculate nucleus, dLGN) remains unknown, as does their relative reliance on surviving rod and cone photoreceptors vs. melanopsin. To answer these questions, we recorded visually evoked responses in the dLGN of anesthetized rd(1) mice using in vivo electrophysiology at an age (3-5 wk) at which cones are partially degenerate and rods are absent. We found that excitatory (ON) responses to light had lower amplitude and longer latency in rd(1) mice compared with age-matched visually intact controls; however, contrast sensitivity and spatial receptive field size were largely unaffected at this early stage of degeneration. Responses were retained when those wavelengths to which melanopsin is most sensitive were depleted, indicating that they were driven primarily by surviving cones. Inhibitory responses appeared absent in the rd(1) thalamus, as did light-evoked gamma oscillations in firing. This description of fundamental features of the dLGN visual response at this intermediate stage of retinal degeneration provides a context for emerging attempts to restore vision by introducing ectopic photoreception to the degenerate retina.
机译：遗传的视网膜退化包括各种疾病，导致杆和锥形光感受器的死亡，最终导致不可逆转的失明。低视力在退化的早期阶段存活，此时它可以依赖于杆/锥形感光体的残余群以及内视网膜感光体，黑色素。迄今为止，部分视网膜退化对初级视觉丘脑（背侧突出核，DLGN）的视觉反应的影响仍然是未知的，它们相对依赖于存活棒和锥形光感受器与黑色素依赖性。为了回答这些问题，我们在锥体在锥体是部分退化的年龄（3-5WK）中使用体内电生理学中使用体内电生理学的DLGN的DLGN中的视觉诱发反应。我们发现，与可见的视觉完整控制的年龄匹配相比，RD（1）小鼠的兴奋性（ON）反应具有较低的幅度和更长的潜伏期;然而，对比度敏感性和空间接收场大小在很大程度上不受变化早期的影响。当黑色素最敏感的那些波长被耗尽时，保留了响应，表明它们主要通过存活锥驱动。 RD（1）丘脑中缺乏抑制反应，如烧制中的光诱发伽马振荡。这种视网膜变性中间阶段的DLGN视觉响应的基本特征的描述提供了通过向退化视网膜引入异位光敏来恢复视觉的新出现的背景。

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