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首页> 外文期刊>Journal of Neurophysiology >Serotonin regulates dynamics of cerebellar granule cell activity by modulating tonic inhibition
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Serotonin regulates dynamics of cerebellar granule cell activity by modulating tonic inhibition

机译：血清素通过调节滋补抑制来调节小脑颗粒细胞活性的动态

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Understanding how afferent information is integrated by cortical structures requires identifying the factors shaping excitation and inhibition within their input layers. The input layer of the cerebellar cortex integrates diverse sensorimotor information to enable learned associations that refine the dynamics of movement. Specifically, mossy fiber afferents relay sensorimotor input into the cerebellum to excite granule cells, whose activity is regulated by inhibitory Golgi cells. To test how this integration can be modulated, we have used an acute brain slice preparation from young adult rats and found that encoding of mossy fiber input in the cerebellar granule cell layer can be regulated by serotonin (5-hydroxytryptamine, 5-HT) via a specific action on Golgi cells. We find that 5-HT depolarizes Golgi cells, likely by activating 5-HT2A receptors. but does not directly act on either granule cells or mossy fibers. As a result of Golgi cell depolarization, 5-HT significantly increases tonic inhibition onto both granule cells and Golgi cells. 5-HT-mediated Golgi cell depolarization is not sufficient, however, to alter the probability or timing of mossy fiber-evoked feed-forward inhibition onto granule cells. Together. increased granule cell tonic inhibition paired with normal feed-forward inhibition acts to reduce granule cell spike probability without altering spike timing. Hence, these data provide a circuit mechanism by which 5-UT can reduce granule cell activity without altering temporal representations of mossy fiber input. Such changes in network integration could enable flexible, state-specific suppression of cerebellar sensorimotor input that should not be learned or enable reversal learning for unwanted associations.
机译：了解如何通过皮质结构集成参与信息，需要识别在其输入层内塑造激励和抑制的因素。小脑CORTEX的输入层集成了不同的感觉电流信息，以实现改进运动动态的学习关联。具体地，苔藓纤维传入将传感器进入小脑进入小脑中以激发颗粒细胞，其活性由抑制性GOLGI细胞调节。为了测试如何调制该集成，我们已经使用了急性脑切片从年轻成年大鼠中制备，发现细胞颗粒细胞层中的苔藓纤维输入的编码可以通过血清素（5-羟基 - 羟基胺，5-HT）通过对高尔基细胞的特定作用。我们发现通过激活5-HT2A受体，可能通过激活5-HT脱极性Golgi细胞。但不直接在颗粒细胞或苔藓纤维上起作用。由于Golgi细胞去极化，5-HT显着提高了滋补细胞和高尔基细胞上的滋补抑制。然而，5-HT介导的GOLGI细胞去极化是不充分的，以改变苔藓纤维诱发前馈抑制到颗粒细胞上的概率或定时。一起。增加颗粒细胞滋补抑制与正常前馈抑制配对的作用，以减少颗粒细胞尖峰概率而不改变尖峰定时。因此，这些数据提供了一种电路机制，通过该电路机构可以减少颗粒电池活动而不改变苔藓光纤输入的时间表示。网络集成的这种变化可以实现灵活的，状态特定的小脑感觉传感器输入，该输入不应学习或为不需要的关联而启用反转学习。

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