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首页> 外文期刊>Journal of Neurophysiology >Abnormally reduced primary motor cortex output is related to impaired hand function in chronic stroke
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Abnormally reduced primary motor cortex output is related to impaired hand function in chronic stroke

机译：异常降低的初级电机皮质输出与慢性冲程中的手功能受损有关

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摘要

Stroke often involves primary motor cortex (M1) and its corticospinal projections (CST). As hand function is critically dependent on these structures, its recovery is often incomplete. The neuronal substrate supporting affected hand function is not well understood but likely involves reorganized M1 and CST of the lesioned hemisphere (M1(IL) and CSTIL ). We hypothesized that affected hand function in chronic stroke is related to structural and functional reorganization of M1(IL) and CSTIL. We tested 18 patients with chronic ischemic stroke involving M1 or CST. Their band function was compared with 18 age-matched healthy subjects. M1(IL) thickness and CSTIL fractional anisotropy (FA) were determined with MRI and compared with measures of the other hemisphere. Transcranial magnetic stimulation (TMS) was applied to M1(IL) to determine its input-output function [stimulus response curve (SRC)]. The plateau of the SRC (MEPmax), inflection point, and slope parameters of the curve were extracted. Results were compared with measures in 12 age-matched healthy controls. MEPmax of M1(IL), was significantly smaller (P = 0.02) in the patients, indicating reduced CSTIL motor output, and was correlated with impaired hand function (P = 0.02). M1(IL) thickness (P 0.01) and CSTIL-FA (P 0.01) were reduced but did not correlate with hand function. The results indicate that employed M1(IL), or CSTIL structural measures do not explain the extent of impairment in hand function once M1 and CST are sufficiently functional for TMS to evoke a motor potential. Instead, impairment of hand function is best explained by the abnormally low output from M1(IL).
机译：中风通常涉及初级运动皮质（M1）及其皮质脊髓突起（CST）。由于手函数批判性地取决于这些结构，其恢复通常不完整。支撑受影响的手功能的神经元基质不太了解，但可能涉及重组的半球（M1（IL）和CSTIL）的重组M1和CST。我们假设影响慢性冲程中的受影响的手功能与M1（IL）和CSTIL的结构和功能重组有关。我们测试了18名患有涉及M1或CST的慢性缺血性卒中患者。与18个匹配的健康受试者进行比较它们的乐队功能。用MRI测定M1（IL）厚度和CSTIL分数各向异性（FA）并与其他半球的测量相比。将经颅磁刺激（TMS）应用于M1（IL）以确定其输入输出功能[刺激响应曲线（SRC）]。提取曲线的SRC（MEPMAX），拐点和斜率参数的高原。将结果与12岁匹配的健康对照中的措施进行了比较。患者M1（IL）的MEPMAX显着较小（P = 0.02），表明CSTIL电动机输出减少，并与手功能受损（P = 0.02）相关。 M1（IL）厚度（P <0.01）和CSTIL-FA（P <0.01）减少但与手功能无关。结果表明，使用M1（IL）或CSTIL结构措施，但是，一旦M1和CST足够挥动动力以引起电动机电位，就不会解释手中损伤程度。相反，通过M1（IL）的异常低输出，最好解释手功能的损伤。

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  • 来源
    《Journal of Neurophysiology》 |2018年第4期|共15页
  • 作者

    Buetefisch C. M.; Revill K. P.; Haut M. W.; Kowalski G. M.; Wischnewski M.; Pifer M.; Belagaje S. R.; Nahab F.; Cubia D. J.; Hu X.; Drake D.; Hobbs G.;

  • 作者单位

    Emory Univ Dept Neurol 1441 Clifton Rd Atlanta GA 30322 USA;

    Emory Univ Dept Psychol Atlanta GA 30322 USA;

    West Virginia Univ Dept Behav Med &

    Psychiat Sch Med Morgantown WV USA;

    Emory Univ Dept Neurol 1441 Clifton Rd Atlanta GA 30322 USA;

    Emory Univ Dept Neurol 1441 Clifton Rd Atlanta GA 30322 USA;

    West Virginia Univ Dept Behav Med &

    Psychiat Sch Med Morgantown WV USA;

    Emory Univ Dept Neurol 1441 Clifton Rd Atlanta GA 30322 USA;

    Emory Univ Dept Neurol 1441 Clifton Rd Atlanta GA 30322 USA;

    Brigham Young Univ Dept Psychol Provo UT 84602 USA;

    Univ Calif Riverside Dept Bioengn Riverside CA 92521 USA;

    Columbia Univ Dept Biostat Mailman Sch Publ Hlth New York NY USA;

    West Virginia Univ Dept Stat Morgantown WV USA;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 人体生理学;
  • 关键词

    human; rehabilitation; stroke;

    机译：人类;康复;中风;

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