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首页> 外文期刊>Journal of Molecular Structure >Green synthesis of nano sized transition metal complexes containing heterocyclic Schiff base: Structural and morphology characterization and bioactivity study
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Green synthesis of nano sized transition metal complexes containing heterocyclic Schiff base: Structural and morphology characterization and bioactivity study

机译：含有杂环席基底碱基纳米尺寸过渡金属配合物的绿色合成：结构与形态学特性和生物活性研究

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In the current involvement of our research work in coordination chemistry, novel transition metal complexes were synthesized from regular reflux method and hydrothermal method using Schiff base prepared via condensation of ethyl 2-amino-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate with 8-carbaldehyde-7-hydroxy-4-methylcoumarin. All the synthesized compounds were interpreted using different analytical, physicochemical and spectral methods such as magnetic moment measurement, FTIR, H-1 and C-13 NMR, GCMS/ESI-MS, UV/Vis spectroscopy and TGA. The size and morphology of the nano metal complexes were determined using atomic force microscope (AFM), field emission scanning electron spectroscopy (FE-SEM) and X-ray powder diffraction (PXRD). The non-electrolytic nature of the metal complexes was confirmed by molar conductance studies. The obtained FT-IR data supports the binding of metal ion to Schiff base. Elemental analysis study suggests [ML2(H2O)(2)] stoichiometry, here M = Co(II), Ni(II) and Cu(II), L = deprotonated ligand. Electronic spectral results reveal six-coordinated geometry for the synthesized metal complexes. All the tested compounds show good DNA cleavage (Calf Thymus DNA) and in vitro anticancer activity (PA-I cell line), the activity results for the tested compounds are prominent and compound 9 exhibited a little enhanced activity than the other tested compounds. (C) 2018 Elsevier B.V. All rights reserved.
机译：在目前，我们在协调化学方面的研究工作中，使用席克碱通过乙基2-氨基-4,5,6,7-四氢苯甲酸缩合制备的辛铵碱来合成新的过渡金属配合物。[B]噻吩-3-羧酸盐8-碳甲醛-7-羟基-4-甲基伞素。使用不同的分析，物理化学和光谱方法来解释所有合成的化合物，例如磁矩测量，FTIR，H-1和C-13 NMR，GCMS / ESI-MS，UV / VIS光谱和TGA。使用原子力显微镜（AFM），场发射扫描电子光谱（Fe-SEM）和X射线粉末衍射（PXRD）测定纳米金属配合物的尺寸和形态。通过摩尔电导研究证实了金属配合物的非电解性质。所获得的FT-IR数据支持金属离子与Schiff底座的结合。元素分析研究表明[ML2（H2O）（2）]化学计量，这里M = CO（II），Ni（II）和Cu（II），L =脱质配体。电子光谱结果显示合成金属配合物的六个协调几何形状。所有测试的化合物都显示出良好的DNA裂解（CALF胸腺DNA）和体外抗癌活性（PA-​​I细胞系），测试化合物的活性结果是突出的，并且化合物9表现出比其他测试化合物的增强的活性略有增强。 （c）2018年elestvier b.v.保留所有权利。

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