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Targeting the cancer-stroma interaction: A potential approach for pancreatic cancer treatment

机译：靶向癌症-基质相互作用：胰腺癌治疗的潜在方法

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Recent studies have demonstrated that the interaction between the cancer and the stroma, play a key role in the development of pancreatic cancer. The desmoplasia, which consists of fibroblasts, pancreatic stellate cells, lymphatic and vascular endothelial cells, immune cells, pathologic increased nerves, and the extracellular matrix (ECM), creates a complex tumor microenvironment that promotes pancreatic cancer development, invasion, metastasis, and resistance to chemotherapy. Thus, the potential approach for targeting the components of this desmoplastic reaction or the pancreatic tumor microenvironment might represent a novel therapeutic approach to advanced pancreatic carcinoma. Novel therapies that target on the pancreatic tumor microenvironment should become one of the more effective treatments for pancreatic cancer.
机译：最近的研究表明，癌症与基质之间的相互作用在胰腺癌的发展中起关键作用。异形增生由成纤维细胞，胰腺星状细胞，淋巴和血管内皮细胞，免疫细胞，病理性神经增多和细胞外基质（ECM）组成，形成了复杂的肿瘤微环境，可促进胰腺癌的发展，侵袭，转移和耐药性去化疗。因此，靶向这种去增生反应或胰腺肿瘤微环境的组分的潜在方法可能代表了晚期胰腺癌的一种新型治疗方法。针对胰腺肿瘤微环境的新型疗法应成为胰腺癌更有效的治疗方法之一。

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