Translational research on lung cancer--EGFR gene mutation

Kosaka T; Endoh H; Yatabe Y; Mitsudomi T

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Translational research on lung cancer--EGFR gene mutation

机译：肺癌翻译研究 - EGFR基因突变

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Recent reports that activating mutations of the EGFR have a significant association with the response to gefitinib drew much attention. Mutations are more frequently observed in Oriental patients, females, non-smokers and adenocarcinoma patients, which correspond to patient profiles predictive of a good clinical response with gefitinib. In vitro experiments also revealed EGFR mutant cell lines are highly sensitive to gefitinib. It seems that development of tailor-made therapy of lung cancer would be possible by the test for EGFR gene mutations. Furthermore, EGFR mutations are the first molecular change known to specifically occur in lung cancer, preferentially in never smokers, especially in adenocarcinoma that is increasing in incidence. It is ultimately necessary to identify non-tobacco-related carcinogens that cause EGFR mutations for effective prevention of lung cancer.

机译：最近的报道称，激活EGFR的突变与对Gefitinib的反应有重大关联，这提高了很多关注。在东方患者，女性，非吸烟者和腺癌患者中更常见的突变，其对应于患者谱预测与吉非替尼的良好临床反应。体外实验还揭示了EGFR突变体细胞系对吉替尼高度敏感。似乎通过测试EGFR基因突变的测试，可以进行量身定制的肺癌治疗的发展。此外，EGFR突变是已知在肺癌中特异性发生的第一种分子变化，优先在从不吸烟者，特别是在发病率增加的腺癌中。最终需要识别非烟草相关的致癌物，导致EGFR突变以有效预防肺癌。

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来源
《癌と化学療法》 |2005年第6期|共9页
作者
Kosaka T; Endoh H; Yatabe Y; Mitsudomi T;
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作者单位

Dept. of Thoracic Surgery Aichi Cancer Center Hospital Nagoya Japan.;

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原文格式 PDF
正文语种 jpn
中图分类肿瘤学;
关键词
c-erbB-1 Proto-Oncogenes; Malignant neoplasm of lung; gene mutation; Research; 研究;

机译：C-ERBB-1原型癌症;肺部恶性肿瘤;基因突变;研究;研究;

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1. Translational research on lung cancer--EGFR gene mutation [J] . Kosaka T, Endoh H, Yatabe Y, 癌と化学療法 . 2005,第6期

机译：肺癌翻译研究 - EGFR基因突变
2. A Dominant Mutation in the Chlamydomonas reinhardtii Nuclear Gene SIM30 Suppresses Translational Defects Caused by Initiation Codon Mutations in Chloroplast Genes [J] . Clare L. Simpson, David B. Stern, Karen L. Kindle, Genetics: A Periodical Record of Investigations Bearing on Heredity and Variation . 1997,第4期

机译：莱茵衣藻核基因SIM30的显性突变抑制了叶绿体基因中起始密码子突变引起的翻译缺陷。
3. Suppression of the Schizosaccharomyces pombe cut12.1 Cell-Cycle Defect by Mutations in cdc25 and Genes Involved in Transcriptional and Translational Control. [J] . Tallada VA, Bridge AJ, Emery PA, Genetics: A Periodical Record of Investigations Bearing on Heredity and Variation . 2007,第1期

机译：通过cdc25突变和涉及转录和翻译控制的基因抑制粟酒裂殖酵母cut12.1细胞周期缺陷。
4. Four Layers Image Representation for Prediction of Lung Cancer Genetic Mutations Based on 2DPCA [C] . Moataz M. Abdelwahab, Shimaa A. Abdelrahman IEEE Pulsed Power Conference . 2017

机译：基于2DPCA的肺癌遗传突变预测的四层图像表示
5. K-ras andp53 mutations and DNA repair genes polymorphisms as biomarkers for lung cancer. [D] . Gao, Weimin. 2003

机译：K-ras和p53突变和DNA修复基因多态性作为肺癌的生物标记。
6. Translational Research in Acute Lung Injury and Pulmonary Fibrosis: The Witschi Hypothesis revisited after 35 years: genetic proof from SP-C BRICHOS domain mutations [O] . Bruce D. Uhal, Hang Nguyen -1

机译：急性肺损伤和肺纤维化的转化研究：35年后重新审视的维茨假说：SP-C BRICHOS域突变的遗传学证据
7. A Dominant Mutation in the Chlamydomonas reinhardtii Nuclear Gene SIM30 Suppresses Translational Defects Caused by Initiation Codon Mutations in Chloroplast Genes [O] . Xuemei Chen, Clare L Simpson, Karen L Kindle, 1997

机译：Chlamydomonas Reinhardtii核基因SIM30中的显性突变抑制了叶绿体基因中引发密码子突变引起的平移缺陷

Translational research on lung cancer--EGFR gene mutation

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