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首页> 外文期刊>癌と化学療法 >Phase I study of concurrent radiotherapy with TS-1 and vitamin A (TAR Therapy) for head and neck cancer
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Phase I study of concurrent radiotherapy with TS-1 and vitamin A (TAR Therapy) for head and neck cancer

机译：I阶段用TS-1和维生素A（TAR治疗）对头部和颈部癌症的同步放射治疗研究

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The triple combination of 5-fluorouracil (5-FU), vitamin A and radiation (FAR therapy) has been effectively used to treat head and neck cancer. The biological anti-tumor effect of 5-FU depends on the activity of its metabolizing enzyme, dihydropyrimidine dehydrogenase (DPD). TS-1 is a novel oral DPD inhibitory fluoropyrimidine (DIF). To improve the anti-tumor effect of FAR therapy, we have applied TS-1 in place of 5-FU injection in the combination of Vitamin A and radiation (TAR therapy). In this study, we have examined the appropriate duration of TS-1 medication and the clinical efficacy and safety of TAR therapy. TS-1 was administered orally at a dose of 65 mg/m2 twice a day. Vitamin A (Retinol Palmitate: 50,000 U/day) was administered intra-musculary on each day of radiation. Radiation was given (1.5-2 Gy/day: 5 days/week) for 30-40 Gy. The levels were divided according to the length of TS-1 application as follows: level 1, 2 weeks; level 2, 3 weeks; level 4, 4 weeks. Grade 4 toxicity of anorexia was observed in one case of level 3. We decided that level 2 (3 weeks of TS-1 administration) was the appropriate length of TS-1 application. TAR therapy is a useful concurrent chemo-radiotherapy which might improve the response rate and QOL of patients with HNSCC.
机译：5-氟尿嘧啶（5-FU），维生素A和辐射（远程治疗）的三倍组合已得到有效地用于治疗头部和颈部癌症。 5-FU的生物抗肿瘤作用取决于其代谢酶的活性，二氢嘧啶脱氢酶（DPD）。 TS-1是一种新型口服DPD抑制氟嘧啶（DIF）。为了提高远程治疗的抗肿瘤作用，我们施用了TS-1代替维生素A和辐射（焦油治疗）的5-FU注射。在这项研究中，我们研究了适当的TS-1药物持续时间和焦油治疗的临床疗效和安全性。 TS-1每天两次以65mg / m 2的剂量口服给药。维生素A（视黄醇棕榈酸酯：50,000 U / Day）在辐射的每一天内施用肌肉内施用。给予辐射（1.5-2 GY /日：5天/周）30-40 GY。根据TS-1申请的长度分割水平，如下：1级，2周; 2级，3周; 4级，4周。在一个水平3的情况下观察到厌食症的4级毒性。我们决定2级（TS-1给药3周）是TS-1申请的适当长度。焦油治疗是一种有用的同步化疗放射疗法，可以改善HNSCC患者的响应率和QoL。

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