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首页> 外文期刊>癌と化学療法 >A case of gastric adenosquamous carcinoma with abdominal paraaortic lymph node metastases successfully treated by TS-1 plus CDDP neoadjuvant chemotherapy
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A case of gastric adenosquamous carcinoma with abdominal paraaortic lymph node metastases successfully treated by TS-1 plus CDDP neoadjuvant chemotherapy

机译：CDDP Neoadjuvant化疗成功处理胃腺腺癌癌患者胃腺腺癌癌，伴有腹膜淋巴结转移

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摘要

A 62-year-old woman was admitted for anemia. An endoscopic examination revealed type 2 cancer from the upper body of the stomach to the antrum, and abdominal CT scan demonstrated enlarged abdominal paraaortic lymph nodes. The preoperative diagnosis was cStage IV gastric cancer (cT 3, cN 3, cH 0, cP 0, cM 0). Since a curative operation was deemed impossible, we conducted neoadjuvant chemotherapy using TS-1 plus cisplatin (CDDP) for downstaging. TS-1( 100 mg/day) was orally administered for 3 weeks,and CDDP (60 mg/m2) was given intravenously on day 8. Appetite loss of grade 3 and erythropenia of grade 1 were observed. After two courses of chemotherapy the primary lesion and the paraaortic lymph nodes were significantly reduced in size. She was judged as clinical PR, followed by distal gastrectomy and lymph node dissection, resulting in curability A. Histopathologically, the tumor was diagnosed as adenosquamous carcinoma of the stomach with lymph node metastasis at only No.3. This case suggests that neoadjuvant chemotherapy using TS-1 plus CDDP is effective for advanced gastric adenosquamous carcinoma with massive lymph node metastases.
机译：一名62岁的女性被贫血录取。内窥镜检查显示来自胃的上半身到胃窦的2型癌症，腹部CT扫描显示出扩大的腹部滞像淋巴结。术前诊断是Cstage IV胃癌（CT 3，CN 3，CH 0，CP 0，CM 0）。由于治疗操作被认为是不可能的，我们使用TS-1加顺铂（CDDP）进行Neoadjuvant化疗进行下间。口服TS-1（100mg /天）施用3周，并在第8天静脉内给予CDDP（60mg / m 2）。观察到3级的食欲损失，1级的促红细胞减少。经过两次化疗疗程，初级病变和滞后淋巴结的大小显着降低。她被判断为临床PR，随后是远端胃切除术和淋巴结解剖，导致可固化A.组织病理学上，肿瘤被诊断为胃的腺瘤性癌，只有淋巴结转移为3号。这种情况表明，使用TS-1加入CDDP的Neoadjuvant化疗对于具有大规模淋巴结转移的晚期胃腺腺瘤性癌是有效的。

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