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首页> 外文期刊>COPD: Journal of Chronic Obstructive Pulmonary Disease >Quantitative airway assessment on computed tomography in patients with alpha1-antitrypsin deficiency.
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Quantitative airway assessment on computed tomography in patients with alpha1-antitrypsin deficiency.

机译：α1-抗胰蛋白酶缺乏症患者的计算机断层扫描定量气道评估。

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摘要

The relationship between quantitative airway measurements on computed tomography (CT) and airflow limitation in individuals with severe alpha (1)-antitrypsin deficiency (AATD) is undefined. Thus, we planned to clarify the relationship between CT-based airway indices and airflow limitation in AATD. 52 patients with AATD underwent chest CT and pre-bronchodilator spirometry at three institutions. In the right upper (RUL) and lower (RLL) lobes, wall area percent (WA%) and luminal area (Ai) were measured in the third, fourth, and fifth generations of the bronchi. The severity of emphysema was also calculated in each lobe and expressed as low attenuation area percent (LAA%). Correlations between obtained measurements and FEV(1)% predicted (FEV(1)%P) were evaluated by the Spearman rank correlation test. In RUL, WA% of all generations was significantly correlated with FEV(1)%P (3rd, R = -0.33, p = 0.02; 4th, R = -0.39, p = 0.004; 5th, R = -0.57, p < 0.001; respectively). Ai also showed significant correlations (3rd, R = 0.32, p = 0.02; 4th, R = 0.34, p = 0.01; 5th, R = 0.56, p < 0.001; respectively). Measured correlation coefficients improved when the airway progressed distally from the third to fifth generations. LAA% also correlated with FEV(1)%P (R = -0.51, p < 0.001). In RLL, WA% showed weak correlations with FEV(1)%P in all generations (3rd, R = -0.34, p = 0.01; 4th, R = -0.30, p = 0.03; 5th, R = -0.31, p = 0.03; respectively). Only Ai from the fifth generation significantly correlated with FEV(1)%P in this lobe (R = 0.34, p = 0.01). LAA% strongly correlated with FEV(1)%P (R = -0.71, p < 0.001). We conclude therefore that quantitative airway measurements are significantly correlated with airflow limitation in AATD, particularly in the distal airways of RUL. Emphysema of the lower lung is the predominant component; however, airway disease also has a significant impact on airflow limitation in AATD.
机译：在具有严重α（1）-抗胰蛋白酶缺乏症（AATD）的个体中，计算机断层扫描（CT）上的定量气道测量与气流受限之间的关系尚不确定。因此，我们计划阐明AATD中基于CT的气道指标与气流受限之间的关系。 52例AATD患者在三个机构接受了胸部CT和支气管扩张剂前肺活量测定。在右上（RUL）和下（RLL）瓣中，测量了第三，第四和第五代支气管的壁面积百分比（WA％）和管腔面积（Ai）。还计算了每个肺叶的肺气肿严重程度，并表示为低衰减面积百分比（LAA％）。通过Spearman秩相关检验评估获得的测量值与预测的FEV（1）％（FEV（1）％P）之间的相关性。在RUL中，所有世代的WA％与FEV（1）％P显着相关（第3位，R = -0.33，p = 0.02;第4位，R = -0.39，p = 0.004;第5位，R = -0.57，p < 0.001;）。 Ai还显示出显着的相关性（分别为3rd，R = 0.32，p = 0.02; 4th，R = 0.34，p = 0.01; 5th，R = 0.56，p <0.001;）。当气道从第三代向第五代前进时，测得的相关系数得到改善。 LAA％也与FEV（1）％P相关（R = -0.51，p <0.001）。在RLL中，WA％在所有世代中均显示与FEV（1）％P的弱相关性（第3，R = -0.34，p = 0.01;第4，R = -0.30，p = 0.03;第5，R = -0.31，p = 0.03;分别）。在这一叶中，只有第五代的Ai与FEV（1）％P显着相关（R = 0.34，p = 0.01）。 LAA％与FEV（1）％P密切相关（R = -0.71，p <0.001）。因此，我们得出结论，定量气道测量与AATD中的气流受限显着相关，尤其是在RUL的远端气道中。下肺气肿是主要成分。然而，气道疾病也对AATD的气流受限产生重大影响。

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