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首页> 外文期刊>COPD: Journal of Chronic Obstructive Pulmonary Disease >Editorial: Significance of polymorphisms in the superoxide dismutase-3 gene in COPD: It's all about location
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Editorial: Significance of polymorphisms in the superoxide dismutase-3 gene in COPD: It's all about location

机译：社论：COPD中超氧化物歧化酶3基因多态性的意义：全都与位置有关

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摘要

Oxidative stress is known to contribute to the pathogenesis of chronic obstructive pulmonary disease (COPD). Cigarette smoke contains high levels of oxidants, which also adds to the oxidative stress in COPD. Endogenous antioxidants are present to scavenge these harmful oxidants and help maintain lung homeostasis. An imbalance in oxidant-antioxidant levels in the lung is detrimental. Indeed, healthy smokers and COPD patients were found to have an impaired oxidant-antioxidant balance as determined by increased plasma levels of malonyldoaldehyde and decreased levels erythrocyte superoxide dismutase enzyme activity.Extracellular superoxide dismutase (EC-SOD or SOD 3) is one member of the superoxide dismutase family of antioxidant enzymes. EC-SOD is mainly located in the extracellular matrix and is highly expressed in arteries and the lung (2). Numerous studies have shown that pulmonary EC-SOD inhibits lung injury in response to variety of pulmonary insults (3-9).
机译：已知氧化应激会导致慢性阻塞性肺疾病（COPD）的发病机理。卷烟烟雾中氧化剂含量很高，这也增加了COPD的氧化应激。存在内源性抗氧化剂，以清除这些有害的氧化剂并帮助维持肺稳态。肺中抗氧化剂水平的不平衡是有害的。确实，发现健康的吸烟者和COPD患者的血浆中丙二酰二醛水平升高，红细胞超氧化物歧化酶活性降低，这决定了氧化剂-抗氧化剂平衡受损。细胞外超氧化物歧化酶（EC-SOD或SOD 3）是其中之一超氧化物歧化酶家族的抗氧化酶。 EC-SOD主要位于细胞外基质中，并在动脉和肺中高表达（2）。大量研究表明，肺EC-SOD可响应多种肺损伤而抑制肺损伤（3-9）。

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