Sympathetic Activation is Associated with Exercise Limitation in COPD

Haarmann Helge; Folle Jan; Xuan Phuc Nguyen; Herrmann Peter; Heusser Karsten; Hasenfuss Gerd; Andreas Stefan; Raupach Tobias

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Sympathetic Activation is Associated with Exercise Limitation in COPD

机译：交感神经激活与COPD中的运动受限有关

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Exercise intolerance, skeletal muscle dysfunction, and reduced daily activity are central in COPD patients and closely related to quality of life and prognosis. Studies assessing muscle exercise have revealed an increase in sympathetic outflow as a link to muscle hypoperfusion and exercise limitation. Our primary hypothesis was that muscle sympathetic nerve activity (MSNA) correlates with exercise limitation in COPD. MSNA was evaluated at rest and during dynamic or static handgrip exercise. Additionally, we assessed heart rate, blood pressure, CO2 tension, oxygen saturation (SpO(2)), and breathing frequency. Ergospirometry was performed to evaluate exercise capacity.

机译：运动不耐受，骨骼肌功能障碍和日常活动减少在COPD患者中很重要，并且与生活质量和预后密切相关。评估肌肉运动的研究表明，交感神经流出增加与肌肉灌注不足和运动受限有关。我们的主要假设是，肌肉交感神经活动（MSNA）与COPD的运动受限有关。对MSNA进行了评估，包括休息时以及动态或静态手握运动时。此外，我们评估了心率，血压，CO2张力，氧饱和度（SpO（2））和呼吸频率。进行人体肺活量测定以评估运动能力。

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《COPD: Journal of Chronic Obstructive Pulmonary Disease》 |2016年第5期|共6页
作者
Haarmann Helge; Folle Jan; Xuan Phuc Nguyen; Herrmann Peter; Heusser Karsten; Hasenfuss Gerd; Andreas Stefan; Raupach Tobias;
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正文语种 eng
中图分类产科学;
关键词
chronic obstructive pulmonary disease; ergospirometry; exercise limitation; handgrip exercise; sympathetic nerve activity;

机译：慢性阻塞性肺疾病;肺活量测定法;运动限制;握力运动;交感神经活动;

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专利

1. Sympathetic Activation is Associated with Exercise Limitation in COPD [J] . Haarmann Helge, Folle Jan, Xuan Phuc Nguyen, COPD: Journal of Chronic Obstructive Pulmonary Disease . 2016,第5期

机译：交感神经激活与COPD中的运动受限有关
2. Targeted ablation of cardiac sympathetic neurons reduces resting, reflex and exercise-induced sympathetic activation in conscious rats [J] . Lujan, H.L., Palani, American Journal of Physiology . 2009,第5aPta2期

机译：针对心脏交感神经神经元的靶向消融减少了有意识的大鼠的休息，反射和运动诱导的交感神经激活
3. Targeted ablation of cardiac sympathetic neurons reduces resting, reflex and exercise-induced sympathetic activation in conscious rats. [J] . Lujan HL, Palani G, Chen Y, American Journal of Physiology . 2009,第5aPta1期

机译：有针对性的心脏交感神经元的消融减少了有意识的大鼠的休息，反射和运动诱导的交感神经激活。
4. Use of a consumer market activity monitoring and feedback device improves exercise capacity and activity levels in COPD [C] . Caulfield Brian, Kaljo Indira, Donnelly Seamas Annual International Conference of the IEEE Engineering in Medicine and Biology Society . 2014

机译：使用消费者市场活动监测和反馈设备可提高COPD的锻炼能力和活动水平
5. Exercise Limitation in Mild COPD: The Role of Respiratory Mechanical Factors [D] . Chin, Roberto Carlos 2012

机译：轻度COPD的锻炼限制：呼吸机械因素的作用
6. Sympathetic limitation of exercise hyperemia: even hypoperfused muscle is not exempted [O] . D. J. Duncker, I. H. Heinonen 2012

机译：运动性充血的交感神经限制：即使灌注不足的肌肉也不能豁免
7. The effect of systemic inflammation on COPD severity and exercise capacity limitation in moderate clinically stable COPD [O] . Al-Shair Khaled, Kolsum Umme, Dockry Rachel, 2010

机译：全身炎症对中度临床稳定期COpD患者COpD严重程度和运动能力限制的影响

Sympathetic Activation is Associated with Exercise Limitation in COPD

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