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首页> 外文期刊>COPD: Journal of Chronic Obstructive Pulmonary Disease >Differential expression of vitamin e and selenium-responsive genes by disease severity in chronic obstructive pulmonary disease
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Differential expression of vitamin e and selenium-responsive genes by disease severity in chronic obstructive pulmonary disease

机译：慢性阻塞性肺疾病中按疾病严重程度区分维生素e和硒反应基因的差异表达

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摘要

Antioxidant nutritional status is hypothesized to influence chronic obstructive pulmonary disease (COPD) susceptibility and progression. Although past studies relate antioxidants to gene expression, there are no data in patients with COPD. This study investigated the hypothesis that antioxidant status is compromised in patients with COPD, and antioxidant-responsive genes differentially express in a similar pattern. Lung tissue samples from patients with COPD were assayed for vitamin E and gene expression. Selenium and vitamin E were assayed in corresponding plasma samples. Discovery based genome-wide expression analysis compared moderate, severe, and very severe COPD (GOLD II-IV) patients to mild and at-riskormal (GOLD 0-I). Hypotheses-driven analyses assessed differential gene expression by disease severity for vitamin E-responsive and selenium-responsive genes. GOLD II-IV COPD patients had 30% lower lung tissue vitamin E levels compared to GOLD 0-I participants (p = 0.0082). No statistically significant genome-wide differences in expression by disease severity were identified. Hypothesis-driven analyses of 109 genes found 16 genes differentially expressed (padjusted < 0.05) by disease severity including 6 selenium-responsive genes (range in fold-change -1.39 to 2.25), 6 vitamin E-responsive genes (fold-change -2.30 to 1.51), and 4 COPD-associated genes. Lung tissue vitamin E in patients with COPD was associated with disease severity and vitamin E-responsive genes were differentially expressed by disease severity. Although nutritional status is hypothesized to contribute to COPD risk, and is of therapeutic interest, evidence to date is mainly observational. The findings reported herein are novel, and support a role of vitamin E in COPD progression.
机译：假设抗氧化剂的营养状况会影响慢性阻塞性肺疾病（COPD）的易感性和进展。尽管过去的研究将抗氧化剂与基因表达相关，但COPD患者尚无数据。这项研究调查了以下假设：COPD患者的抗氧化状态受到损害，并且抗氧化反应基因以相似的方式差异表达。分析来自COPD患者的肺组织样品中的维生素E和基因表达。在相应的血浆样品中测定了硒和维生素E。基于发现的全基因组表达分析将中度，重度和非常重度的COPD（GOLD II-IV）患者与轻度和高危/正常（GOLD 0-I）患者进行了比较。假设驱动的分析通过疾病严重程度评估了维生素E敏感和硒敏感基因的差异基因表达。与GOLD 0-I参与者相比，GOLD II-IV COPD患者的肺组织维生素E水平降低了30％（p = 0.0082）。没有发现按疾病严重程度表达的全基因组差异。假设驱动的109个基因分析发现16个基因因疾病严重程度而差异表达（调整至<0.05），包括6个硒敏感基因（倍数变化范围-1.39至2.25），6个维生素E敏感基因（倍数变化-2.30）至1.51）和4个COPD相关基因。 COPD患者的肺组织维生素E与疾病严重程度相关，而维生素E反应基因则根据疾病严重程度而差异表达。尽管假定营养状况会导致COPD风险，并且具有治疗意义，但迄今为止的证据主要是观察性的。本文报道的发现是新颖的，并且支持维生素E在COPD进展中的作用。

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