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首页> 外文期刊>COPD: Journal of Chronic Obstructive Pulmonary Disease >Elastin degradation products as biomarkers in alpha-1 antitrypsin deficiency: Lastin' impact?
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Elastin degradation products as biomarkers in alpha-1 antitrypsin deficiency: Lastin' impact?

机译：弹性蛋白降解产物作为α-1抗胰蛋白酶缺乏症的生物标志物：lastin'的影响？

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摘要

Biomarkers for emphysema and specifically for alpha-1 antitrypsin deficiency (AATD)-related emphysema have been investigated vigorously because biomarkers offer the promise of important benefits such as assessing disease status, monitoring disease progression, assessing the effects of therapy, and providing important outcome measures for research. Because of these promising benefits, the appetite to identify validated biomarkers for emphysema is now greater than ever. Among the many biomarkers for emphysema that have been considered to date (e.g., radiographic measures, biochemical tests, patient-centered instrument-based assessments, etc.), desmosine and isodesmosine have held longstanding appeal because of a compelling model by which they should reflect emphysema progression. As pointed out by Ma et al. (1) in the accompanying article, desmosine and isodesmosine (DI) occur as amino acid cross-links only in mature elastin, a major (though not exclusive) source of which is the lung. The underlying model has been that, as emphysema progresses, elastin is degraded, and its degradation products, DI, will appear in increased amounts in various fluids such as plasma, urine, and bronchoalveo-lar fluid (BALF). Interest in DI as a biomarker in AATD has been steady, with multiple available studies spanning almost two decades (2-5).
机译：肺气肿的生物标志物，尤其是与α-1抗胰蛋白酶缺乏症（AATD）相关的肺气肿的生物标志物已得到了广泛研究，因为生物标志物有望带来重要的益处，例如评估疾病状况，监测疾病进展，评估治疗效果以及提供重要的结局指标用于研究。由于这些有希望的好处，现在比以往任何时候都更需要鉴定经验证的肺气肿生物标志物。迄今为止已考虑的许多肺气肿生物标志物（例如，放射线照相，生化检查，以患者为中心的基于仪器的评估等）中，地塞辛和异地塞莫因具有令人信服的模型而长期以来受到人们的青睐。肺气肿进展。正如Ma等人指出的。 （1）在随附的文章中，地精和异地精（DI）仅在成熟的弹性蛋白中以氨基酸交联的形式出现，而弹性蛋白的主要来源（尽管不是排他性的）是肺。潜在的模型是，随着肺气肿的发展，弹性蛋白会降解，其降解产物DI在各种液体（例如血浆，尿液和支气管肺泡液（BALF））中的含量会增加。人们对DI作为AATD的生物标记物的兴趣一直稳定，已有近20年的大量可用研究（2-5）。

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