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首页> 外文期刊>COPD: Journal of Chronic Obstructive Pulmonary Disease >Computed tomography biomarkers of pulmonary emphysema
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Computed tomography biomarkers of pulmonary emphysema

机译:肺气肿的计算机断层扫描生物标志物

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摘要

The use of computed tomography (CT) scanning to assess emphysema has exploded since the mid-1980s. Since the definition of emphysema, permanent enlargement of airspaces and destruction of alveolar walls (1) is a structural definition and pathologic examination of tissue is limited to post-mortem or resected specimens, CT has been become very popular because it allows investigators and clinicians to obtain useful, relatively non-invasive structural information about the lung (2-4). The exquisite anatomic information that CT provides has resulted in a proliferation of CT devices throughout the world such that virtually every hospital and research organization in the developed world now has easy access to a CT scanner. The end result is that almost all investigators have access to high quality images of the lung for clinical and research purposes. Another important advantage of CT is that, unlike clinical or physiological measurements of airflow limitation, it can differentiate between the contributions of emphysema and airways disease-the two underlying phenotypes in patients with chronic obstructive pulmonary disease (COPD).
机译:自1980年代中期以来,使用计算机断层扫描(CT)扫描评估肺气肿的用途已激增。由于肺气肿的定义,气隙的永久扩大和肺泡壁的破坏(1)是结构性定义,并且组织病理学检查仅限于验尸或切除标本,因此CT变得非常流行,因为它允许研究者和临床医生进行获得有用的,相对无创的关于肺的结构信息(2-4)。 CT提供的精美解剖信息已导致CT设备在世界范围内激增,因此,发达国家中的几乎每家医院和研究机构现在都可以轻松使用CT扫描仪。最终结果是,几乎所有研究人员都可以出于临床和研究目的获得高质量的肺部图像。 CT的另一个重要优点是,与临床或生理上对气流受限的测量不同,它可以区分肺气肿和气道疾病的贡献-慢性阻塞性肺疾病(COPD)患者的两种潜在表型。

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