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首页> 外文期刊>COPD: Journal of Chronic Obstructive Pulmonary Disease >Chronic obstructive pulmonary disease in stage i non-small cell lung cancer that underwent anatomic resection: The role of a recurrence promoter
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Chronic obstructive pulmonary disease in stage i non-small cell lung cancer that underwent anatomic resection: The role of a recurrence promoter

机译：进行解剖切除的第i期非小细胞肺癌的慢性阻塞性肺疾病：复发促进剂的作用

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Background: Despite the use of anatomic resection, the post-surgical recurrence rate remains high in early-stage non-small cell lung cancer (NSCLC). Chronic inflammation plays a role in the mechanism that promotes tumor initiation. This study aimed to investigate the association between recurrence outcome and chronic inflammation-related co-morbidities in early-stage resected NSCLC. Methods: A review of medical records for recurrence outcome and co-morbidities, in terms of chronic obstructive pulmonary disease (COPD), DM, asthma and cardiovascular diseases, was performed with 181 patients with stage I NSCLC that underwent anatomic resection. Results: Subjects with T descriptors as T2a disease (49.5 vs. 28.0%, p < 0.05) and the presence of COPD (42.4 vs. 20.7%, p < 0.01) had a higher risk of tumor recurrence. Univariate analysis for recurrence-free survival showed T descriptor as T2a (21.5 months vs. NR, p < 0.05) and the presence of COPD (20.5 months vs. NR, p < 0.01) as significant factors predicting reduced survival. The presence of COPD (HR: 1.98; 95% CI, 1.29-.02, p < 0.01) and T descriptor as T2a (HR: 2.01; 95% CI, 1.04-3.91, p < 0.05) remain independent predictors of reduced recurrence-free survival in the Cox regression model. Patients with COPD were at higher risk of brain recurrence (OR: 7.88; 95% CI, 1.50-41.3, p < 0.01). In contrast, patients without COPD showed a tendency toward recurrence in bone and liver (OR: 4.13; 95% CI, 1.08-15.8, p = 0.05). Conclusion: Subjects with COPD and T2a disease had a higher risk of recurrence. The role of COPD as a recurrence promoter merits further prospective investigation.
机译：背景：尽管采用了解剖切除术，早期非小细胞肺癌（NSCLC）的术后复发率仍然很高。慢性炎症在促进肿瘤发生的机制中起作用。这项研究旨在调查早期切除的非小细胞肺癌的复发结局与慢性炎症相关合并症之间的关系。方法：对181例接受I期NSCLC手术切除的I期非小细胞肺癌患者的慢性阻塞性肺疾病（COPD），糖尿病，哮喘和心血管疾病的复发和合并症的病历进行了回顾。结果：T描述为T2a疾病（49.5 vs. 28.0％，p <0.05）且存在COPD（42.4 vs. 20.7％，p <0.01）的受试者发生肿瘤的风险更高。无复发生存期的单因素分析显示，T描述符为T2a（21.5个月vs. NR，p <0.05）和COPD的存在（20.5个月vs. NR，p <0.01）是预测生存率降低的重要因素。 COPD（HR：1.98; 95％CI，1.29-.02，p <0.01）和T描述符为T2a（HR：2.01; 95％CI，1.04-3.91，p <0.05）的存在仍然是复发率降低的独立预测因子Cox回归模型中的无生存期。 COPD患者的脑复发风险更高（或：7.88; 95％CI，1.50-41.3，p <0.01）。相反，没有COPD的患者则显示出骨和肝有复发的趋势（OR：4.13; 95％CI，1.08-15.8，p = 0.05）。结论：患有COPD和T2a疾病的受试者复发风险更高。 COPD作为复发促进剂的作用值得进一步的前瞻性研究。

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