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首页> 外文期刊>Biosensors & Bioelectronics: The International Journal for the Professional Involved with Research, Technology and Applications of Biosensers and Related Devices >Electrochemical sensor based on molecularly imprinted film at Au nanoparticles-carbon nanotubes modified electrode for determination of cholesterol
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Electrochemical sensor based on molecularly imprinted film at Au nanoparticles-carbon nanotubes modified electrode for determination of cholesterol

机译：基于金纳米颗粒-碳纳米管修饰电极上分子印迹膜的电化学传感器测定胆固醇

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A novel electrochemical sensor for cholesterol (CHO) detection based on molecularly imprinted polymer (MIP) membranes on a glassy carbon electrode (GCE) modified with multi-walled carbon nanotubes (MWNTs) and Au nanoparticles (AuNPs) was constructed. p-Aminothiophenol (P-ATP) and CHO were assembled on the surface of the modified GCE by the formation of Au-S bonds and hydrogen-bonding interactions, and polymer membranes were formed by electropolymerization in a polymer solution containing p-ATP, HAuCl4, tetrabutylammonium perchlorate (TBAP) and the template molecule CHO. Cyclic voltammetry (CV) and differential pulse voltammetly (DPV) measurements were used to monitor the electropolymerization process and its optimization, which was further characterized by scanning electron microscopy (SEM). The linear response range of the MIP sensor was between 1 x 10(-13) and 1 x 10(-9) mol L-1, and the limit of detection CLOD) were 3.3 x 10(-14) mol L-1. The proposed system has the potential for application in clinical diagnostics of cholesterol with high-speed real-time detection capability, low sample consumption, high sensitivity, low interference and good stability. (C) 2014 Elsevier B.V. All rights reserved.
机译：基于多壁碳纳米管（MWNTs）和金纳米颗粒（AuNPs）修饰的玻璃碳电极（GCE）上的分子印迹聚合物（MIP）膜，构建了一种用于胆固醇（CHO）检测的新型电化学传感器。通过形成Au-S键和氢键相互作用将对氨基硫酚（P-ATP）和CHO组装在改性GCE的表面上，并在含p-ATP，HAuCl4的聚合物溶液中通过电聚合形成聚合物膜。 ，高氯酸四丁铵（TBAP）和模板分子CHO。循环伏安法（CV）和微分脉冲伏安法（DPV）测量用于监测电聚合过程及其优化，并通过扫描电子显微镜（SEM）对其进行进一步表征。 MIP传感器的线性响应范围为1 x 10（-13）mol L-1，检测限CLOD）为3.3 x 10（-14）mol L-1。所提出的系统具有高速实时检测能力，低样品消耗，高灵敏度，低干扰和良好的稳定性，可用于胆固醇的临床诊断。 （C）2014 Elsevier B.V.保留所有权利。

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