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首页> 外文期刊>Biosensors & Bioelectronics: The International Journal for the Professional Involved with Research, Technology and Applications of Biosensers and Related Devices >Towards the rational development of molecularly imprinted polymers: H-1 NMR studies on hydrophobicity and ion-pair interactions as driving forces for selectivity
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Towards the rational development of molecularly imprinted polymers: H-1 NMR studies on hydrophobicity and ion-pair interactions as driving forces for selectivity

机译：朝着分子印迹聚合物的合理发展：H-1 NMR研究疏水性和离子对相互作用作为选择性驱动力

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The preparation of molecularly imprinted polymers (MIP) based on non-covalent interactions has become a widely used technique for creating highly specific sorbent materials predominantly used in separation chemistry. A crucial factor in a successful imprinting protocol is the optimisation of the template/functional monomer interaction in the pre-polymerisation mixture, eventually leading to a maximum of high-affinity binding sites in the resulting polymer matrix. In order to develop more efficient preparation technologies for imprinted polymers, two separate pre-polymerisation complexes were investigated by NMR spectroscopic techniques in order to identify the types of interactions occurring in the pre-polymerisation mixture, and their implications for the subsequently formed imprinted polymer. In particular, hydrophobic effects have been followed by NMR spectroscopy and their contribution to the selectivity of the resulting MIP has been investigated. The 2,4-D imprint system is used as an example to fundamentally study whether observations at the pre-polymerisation stage correlate with properties of the finally prepared MIP, and which parameters govern success of an imprinting protocol. (C) 2004 Elsevier B.V. All rights reserved.
机译：基于非共价相互作用的分子印迹聚合物（MIP）的制备已成为一种广泛使用的技术，用于创建主要用于分离化学的高特异性吸附剂材料。成功的印迹方案的关键因素是预聚合混合物中模板/功能性单体相互作用的优化，最终导致所得聚合物基质中具有最大的高亲和力结合位点。为了开发用于印迹聚合物的更有效的制备技术，通过NMR光谱技术研究了两种单独的预聚合络合物，以鉴定在预聚合混合物中发生的相互作用的类型及其对随后形成的印迹聚合物的影响。特别是，通过NMR光谱跟踪了疏水效应，并研究了它们对所得MIP选择性的贡献。以2，4-D压印系统为例，从根本上研究预聚合阶段的观察结果是否与最终制备的MIP的特性相关，以及哪些参数控制着压印协议的成功。 （C）2004 Elsevier B.V.保留所有权利。

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