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Consistency and accuracy of the Medical Subject Headings (R) thesaurus for electronic indexing and retrieval of chronobiologic references

机译:电子主题索引和年代生物学参考文献检索的医学主题词表(R)同义词库的一致性和准确性

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The aim of this study was to investigate the reliability of the National Library of Medicine (NLM)'s Medical Subject Headings((R)) (MeSH) thesaurus for electronic indexing and retrieval of published chronobiologic papers. A sample set of 228 recent chronobiologic references was downloaded from the MEDLINE (R)'s database together with all MeSH entries associated with them. The following descriptors were analyzed among the headings of obvious chronobiologic relevance: chronobiology, chronobiology disorders, biological clocks, circadian rhythm, chronotherapy, drug administration schedule, periodicity, seasons, sleep disorders/circadian rhythm, and time factors. A comparison was made between the number of references identified by each heading and the number of articles actually pertinent to the same heading (as ascertained after reading each article of the sample set). This made possible an assessment of consistency (retrieved number not less than actual number) and accuracy (retrieved number not greater than actual number) of the usage of each MeSH entry. By reading each article, it was also possible to identify common chronobiologic concepts not yet associated with specific MeSH headings. In the preselected set of chronobiologic references, seasons identified all articles pertinent to seasonal variations and rhythms. However, chronobiology disorders missed 97.6% of its pertinent articles; periodicity, 95.2%; chronobiology, 87.7%; chronotherapy, 70%; time factors, 62.3%; and sleep disorders/circadian rhythm, 47.4%. Drug administration schedule missed 40% of the chronotherapeutic articles and identified 15% of the chronopharmacologic articles; biological clocks missed 24.1 % of its pertinent articles and wrongly identified 8.3% of the retrieved articles; and circadian rhythm missed 2.7% of all circadian studies and wrongly identified 8.2% of the articles it retrieved. When used to search chronobiologic articles in the entire MEDLINE database, drug administration schedule, seasons, and time factors appeared to lack sufficient specificity to produce accurate results. Some common chronobiologic concepts were found not to be associated with any specific MeSH heading, namely, chronoepidemiology, chronopharmacology, chronotoxicology, chronotype, entrainment, and masking. For common chronobiologic concepts and definitions, the use of available MeSH headings appears to often yield inconsistent and inaccurate results; moreover, the MeSH thesaurus remains incomplete. (Author correspondence: prf@unife.it).
机译:这项研究的目的是调查国家医学图书馆(NLM)的医学主题词表(MeSH)词库用于电子索引和检索已发表的年代生物学论文的可靠性。从MEDLINE(R)的数据库中下载了228个最新的年代生物学参考文献的样本集,以及与之相关的所有MeSH条目。在明显的年代生物学相关性的标题中分析了以下描述符:年代生物学,年代生物学疾病,生物钟,昼夜节律,时间疗法,药物给药时间表,周期性,季节,睡眠障碍/昼夜节律和时间因素。在每个标题所标识的参考文献数量与与该标题实际相关的文章数量之间进行了比较(在阅读样本集的每个文章后确定)。这使得可以评估每个MeSH条目的使用的一致性(检索的数量不少于实际数量)和准确性(检索的数量不少于实际数量)。通过阅读每篇文章,还可以识别尚未与特定MeSH标题关联的常见年代生物学概念。在预先选择的时间生物学参考资料集中,季节确定了与季节变化和节奏有关的所有文章。但是,年代生物学疾病漏掉了其相关文章的97.6%;周期性,95.2%;时间生物学,87.7%;计时疗法,占70%;时间因素,占62.3%;和睡眠障碍/昼夜节律,占47.4%。药物管理时间表遗漏了40%的计时治疗用品,并确定了15%的计时药理用品;生物钟错过了其相关文章的24.1%,并错误地识别了所检索文章的8.3%;而昼夜节律错过了所有昼夜节律研究的2.7%,并错误地确定了其检索到的文章的8.2%。当用于在整个MEDLINE数据库中搜索年代生物学文章时,药物给药时间表,季节和时间因素似乎缺乏足够的特异性来产生准确的结果。发现一些常见的年代生物学概念与任何特定的MeSH标题均不相关,即年代流行病学,年代药理学,年代毒理学,年代型,夹带和掩盖。对于常见的时间生物学概念和定义,使用可用的MeSH标题似乎常常产生不一致和不准确的结果。此外,MeSH词库仍然不完整。 (作者通讯:prf@unife.it)。

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