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首页> 外文期刊>Chronobiology international >The suitability of actigraphy, diary data, and urinary melatonin profiles for quantitative assessment of sleep disturbances in schizophrenia: A case report
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The suitability of actigraphy, diary data, and urinary melatonin profiles for quantitative assessment of sleep disturbances in schizophrenia: A case report

机译：行为学，日记数​​据和泌尿褪黑激素谱在精神分裂症睡眠障碍定量评估中的适用性：一例报告

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Sleep disruption is a commonly encountered clinical feature in schizophrenic patients, and one important concern is to determine the extent of this disruption under "real" life situations. Simultaneous wrist actigraphy, diary records, and repeated urine collection for urinary 6-sulphatoxymelatonin (aMT6s) profiles are appropriate tools to assess circadian rhythms and sleep patterns in field studies. Their suitability for long-term recordings of schizophrenic patients living in the community has not been evaluated. In this case report, we document long-term simultaneous wrist actigraphy, light detection, repeated urine collection, and diary records as a suitable combination of non-invasive techniques to quantify and assess changes in sleep-wake cycles, light exposure, and melatonin profiles in a schizophrenic patient. The actigraph was well-tolerated by the patient, and compliance to diary records and 48 h urine collection was particularly good with assistance from family members. The data obtained by these techniques are illustrated, and the results reveal remarkable abnormal patterns of rest-activity patterns, light exposure, and melatonin production. We observed various rest-activity patterns, including phase-shifts, highly delayed sleep on- and offsets, and irregular rest-activity phases. The period of the rest-activity rhythm, light-dark cycle, and melatonin rhythm was longer than 24 h. These circadian abnormalities may reinforce the altered sleep patterns and the problems of cognitive function and social engagement associated with schizophrenic.
机译：睡眠中断是精神分裂症患者中经常遇到的临床特征，并且一个重要的关注点是确定在“真实”生活情况下这种中断的程度。同时进行手腕肌电记录，日记记录和重复收集尿液中的6-sulphatoxymelatonin（aMT6s）概况尿液是在田间研究中评估昼夜节律和睡眠方式的合适工具。尚未评估它们是否适合长期记录社区中的精神分裂症患者。在此病例报告中，我们记录了长期同时进行的腕部活动记录，光检测，重复尿液收集和日记记录，以作为非侵入性技术的合适组合，以量化和评估睡眠-觉醒周期，光照和褪黑激素的变化在精神分裂症患者中。病人对书法记录仪的耐受性很好，在家庭成员的协助下，对日记记录和48 h尿液收集的依从性特别好。说明了通过这些技术获得的数据，结果揭示了休息活动模式，曝光和褪黑激素产生的异常模式。我们观察到各种休息活动模式，包括相移，高度延迟的睡眠时间和偏移以及不规则的休息活动阶段。静息活动节律，明暗周期和褪黑激素节律的周期超过24小时。这些昼夜节律异常可能会加剧睡眠方式的改变以及与精神分裂症有关的认知功能和社交参与的问题。

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