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首页> 外文期刊>Academic radiology >Quantitative measurement of lung reexpansion in malignant pleural mesothelioma patients undergoing pleurectomy/decortication.
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Quantitative measurement of lung reexpansion in malignant pleural mesothelioma patients undergoing pleurectomy/decortication.

机译：恶性胸膜间皮瘤/胸膜剥脱术的恶性胸膜间皮瘤患者肺膨胀的定量测量。

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RATIONALE AND OBJECTIVES: Malignant pleural mesothelioma (MPM) is a neoplasm that grows circumferentially along the pleura. The tumor and concurrent pleural effusion may reduce lung function by restricting or preventing lung expansion. The purpose of this study was to provide objective evidence that pleurectomy/decortication (P/D) allows trapped lung to reexpand, quantify the reexpansion based on computed tomography (CT) scans, and investigate whether the expansion persists after surgery. MATERIALS AND METHODS: A database of 12 patients demonstrating unilateral MPM was collected. Each patient underwent a presurgical CT scan, surgical debulking by P/D, and two postsurgical CT scans (at 1 and 4 months). The lung volume was measured in each scan using an automated algorithm and compared for each patient across time. RESULTS: An increase in the ipsilateral postsurgical lung volume was observed for 10 of 12 patients (83%) 1 month after surgery. The median ipsilateral volume increase was 44% relative to the presurgical ipsilateral volume and 21% relative to the contralateral volume. A statistically significant change in ipsilateral lung volume was not observed between 1month and 4month postsurgical scans, implying that the volume improvement persisted months after surgery. CONCLUSIONS: Debulking of MPM with P/D substantially increased the ipsilateral lung volume relative to both the presurgical ipsilateral volume and the contralateral lung volume. This improvement persisted months after surgery.
机译：理由和目的：恶性胸膜间皮瘤（MPM）是一种沿胸膜沿周向生长的肿瘤。肿瘤和并发的胸腔积液可通过限制或阻止肺扩张而降低肺功能。这项研究的目的是提供客观证据，证明胸膜切除术/去皮（P / D）可以使被困的肺部扩大，根据计算机断层扫描（CT）扫描量化这种扩大，并调查术后扩大是否持续。材料与方法：收集了12例单方面MPM患者的数据库。每例患者均接受术前CT扫描，通过P / D进行手术切除以及两次术后CT扫描（分别为1和4个月）。使用自动算法在每次扫描中测量肺体积，并随时间对每个患者进行比较。结果：术后1个月，在12例患者中有10例（83％）患侧同侧肺体积增加。相对于术前同侧体积，中位同侧体积增加为44％，相对于对侧体积为21％。在术后1个月至4个月扫描期间，未观察到同侧肺体积的统计学显着变化，这意味着在术后数月内，肺体积持续改善。结论：相对于术前同侧肺体积和对侧肺体积而言，P / D减轻MPM的体积可显着增加同侧肺体积。术后几个月，这种改善持续存在。

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