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首页> 外文期刊>Academic radiology >The frequency and spectrum of thymus 2-(fluorine-18) fluoro-2-deoxy-D-glucose uptake patterns in hyperthyroidism patients.
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The frequency and spectrum of thymus 2-(fluorine-18) fluoro-2-deoxy-D-glucose uptake patterns in hyperthyroidism patients.

机译：甲状腺功能亢进患者胸腺2-（氟-18）氟-2-脱氧-D-葡萄糖摄取模式的频率和频谱。

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RATIONALE AND OBJECTIVES: Thymic hyperplasia is associated with hyperthyroidism. Increased thymus 2-[fluorine-18]fluoro-2-deoxy-D-glucose (FDG) uptake in hyperthyroidism patients has been reported. The aim of this study was to analyze the FDG positron emission tomography (PET) thymus uptake spectrum in patients with active hyperthyroidism with correlation with serum hormones. MATERIALS AND METHODS: The prospective study included FDG PET scans from 65 hyperthyroidism patients and 30 subjects with euthyroid status as control group. The intensity of FDG uptake in thyroid and thymus regions was graded subjectively on a five-point scale and semi-quantitatively by measuring standard uptake value (SUV). Correlation coefficient between thymus SUV and serum thyroxine, triiodothyronine, thyrotropin, thyroid peroxidase antibodies (TPO Ab), thyrotropin receptor autoantibody (TR Ab), and thymulin were analyzed. RESULTS: Among 65 hyperthyroidism patients, 30 (46.2%) and 39 (60%) patients showed thyroid and thymus FDG uptake, respectively. The frequency of thymus uptake FDG was high in patients younger than age 40 (28/31, 90.3%). The patterns of the thymic FDG uptake include inverted V or triangular, separated triangular, united nontriangular, unilateral right or left extension, and focal midline. Focal midline FDG uptake was the most common pattern (15/39, 38.5%). None of the control group showed thymus FDG uptake. The correlation coefficient between the FDG uptake SUV levels in thymus and serum hormones, thyrotropin, TPO Ab, TR Ab, and thymulin levels were all low (P > .05). CONCLUSIONS: In FDG PET scan, thymus activity was common in hyperthyroidism patients; this should not be misdiagnosed as a malignancy in patients exhibiting weight loss.
机译：理由和目的：胸腺增生与甲状腺功能亢进有关。甲状腺功能亢进症患者胸腺2- [氟-18]氟-2-脱氧-D-葡萄糖（FDG）的摄取增加。这项研究的目的是分析活动性甲状腺功能亢进症患者的FDG正电子发射断层扫描（PET）胸腺摄取谱，并与血清激素相关。材料与方法：前瞻性研究包括来自65例甲亢患者和30例甲状腺功能正常的受试者的FDG PET扫描。甲状腺和胸腺区域中FDG摄取的强度通过测量标准摄取值（SUV）在五点量表上进行主观评分，并在半定量上进行评分。分析了胸腺SUV与血清甲状腺素，三碘甲状腺素，甲状腺素，甲状腺过氧化物酶抗体（TPO Ab），促甲状腺素受体自身抗体（TR Ab）和胸腺素之间的相关系数。结果：在65例甲亢患者中，分别有30例（46.2％）和39例（60％）甲状腺和胸腺FDG摄取。 40岁以下的患者胸腺摄取FDG的频率较高（28 / 31，90.3％）。胸腺FDG摄取的模式包括倒V形或三角形，分离的三角形，统一的非三角形，单侧向右或向左延伸以及局中中线。焦点中线FDG摄取是最常见的模式（15 / 39，38.5％）。对照组均未显示胸腺FDG摄取。胸腺中FDG摄取SUV水平与血清​​激素，促甲状腺激素，TPO Ab，TR Ab和胸腺素水平之间的相关系数均较低（P> .05）。结论：在FDG PET扫描中，甲状腺功能亢进患者的胸腺活性很常见。这不应被误诊为体重减轻患者的恶性肿瘤。

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