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首页> 外文期刊>Academic radiology >Proton MR Spectroscopy of Central Neurocytoma Using Short and Long Echo Time. New Proofs for the Existence of Glycine and Glutamate
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Proton MR Spectroscopy of Central Neurocytoma Using Short and Long Echo Time. New Proofs for the Existence of Glycine and Glutamate

机译：质子磁共振波谱中枢神经细胞瘤使用短和长回波时间。甘氨酸和谷氨酸存在的新证据

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Rationale and Objectives: Central neurocytomas (CNCs) are rare benign tumors typically located in the lateral ventricle of the central nervous system. The authors report five patients with CNCs and review 16 previously published studies that included 52 patients with CNCs to explore the magnetic resonance spectroscopic features of CNCs. Materials and Methods: Five patients with CNCs were retrospectively reviewed. They were examined using point-resolved spectroscopic series with short and/or long echo times. The integrals of choline, creatine, and the 3.55-ppm peak were determined using Magnetic Resonance User Interface software, and the metabolite ratios relative to creatine were obtained. In two cases, T2 relaxation times of choline and the metabolite resonance at 3.55 ppm were calculated using data points acquired with different echo times and an exponential decay model. Results: Consistent with previously published studies, all five patients showed highly increased choline and reduced N-acetylaspartate and creatine. Four patients in the present study and 35 in published data demonstrated prominent peaks at 3.55 ppm, which were assigned to glycine because of its relaxation pattern and long T2 relaxation time. In addition, increased in vivo glutamate and glutamine was also confirmed in three patients examined with short echo times. Alanine and lactate peaks were observed in three and two patients, respectively. Conclusions: The present study shows that the 3.55-ppm peak characteristic of CNC should be assigned to glycine according to its T2 relaxation time. Besides increased glycine and choline, the presence of glutamate or glutamine, which appears on series with short echo times, may further confirm the diagnosis of CNC.
机译：原理和目的：中枢神经细胞瘤（CNC）是罕见的良性肿瘤，通常位于中枢神经系统的侧脑室。作者报告了5例CNC患者，并回顾了16篇先前发表的研究，其中包括52例CNC患者，以探讨CNC的磁共振波谱特征。资料与方法：回顾性分析5例CNC患者。使用具有短和/或长回波时间的点分辨光谱系列对它们进行了检查。使用磁共振用户界面软件确定胆碱，肌酸和3.55-ppm峰的积分，并获得相对于肌酸的代谢物比率。在两种情况下，使用通过不同回波时间获得的数据点和指数衰减模型计算胆碱的T2弛豫时间和3.55 ppm处的代谢物共振。结果：与先前发表的研究一致，所有五名患者的胆碱含量均显着升高，N-乙酰天门冬氨酸和肌酸含量降低。本研究中的四位患者和已发表的数据中的35位患者在3.55 ppm处显示出明显的峰，由于其松弛模式和较长的T2松弛时间，它们被分配给甘氨酸。此外，在三名回声时间短的患者中也证实了体内谷氨酸和谷氨酰胺的增加。分别在三名和两名患者中观察到丙氨酸和乳酸峰。结论：本研究表明，CNC的3.55-ppm峰特征应根据其T2弛豫时间分配给甘氨酸。除甘氨酸和胆碱含量增加外，以短回波时间出现在系列中的谷氨酸或谷氨酰胺的存在可能进一步证实CNC的诊断。

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